Evidence map›Paper›PMID 38813598›Full record

ReviewTropical medicine & international health : TM & IH2024

Rickettsia africae infections in sub-Saharan Africa: A systematic literature review of epidemiological studies and summary of case reports.

Elizabeth Y Zhang, Prarthana Kalmath, Haley A Abernathy, Dana A Giandomenico, Melissa S Nolan, Michael H Reiskind, Ross M Boyce

Abstract readReview
In one paragraph

Review in Tropical medicine & international health : TM & IH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth Y ZhangCollege of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Prarthana KalmathCollege of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Haley A AbernathyInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Dana A GiandomenicoInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Melissa S NolanDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Michael H ReiskindDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, USA.
Ross M BoyceInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Serial Killers to Mosquitos: The Spatial Targeting of Larval habitats in rural Uganda using geographic ProfilingK23AI141764 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOYCE, ROSS MATHEW · 2019 to 2023
$944k
by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health UM1TR004406Doris Duke Charitable Foundation 2015213National Institutes of Allergy and Infectious Diseases (NIAID) K23AI141764NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NIAID NIH HHS K23 AI141764the North Carolina Translational and Clinical Sciences (NC TraCS) Institute
6 · The paper itself

Abstract

Rickettsia africae is a tick-borne bacteria known to cause African tick bite fever (ATBF). While the disease was first described more than 100 years ago, knowledge of transmission risk factors and disease burden remain poorly described. To better understand the burden of R. africae, this article reviewed and summarized the published literature related to ATBF epidemiology and clinical management. Using a systematic approach, consistent with the PRISMA guidelines, we identified more than 100 eligible articles, including 65 epidemiological studies and 41 case reports. Most reports described R. africae in ticks and livestock, while human studies were less common. Human disease case reports were exclusively among returning travellers from non-endemic areas, which limits our disease knowledge among at-risk populations: people living in endemic regions. Substantial efforts to elucidate the ATBF risk factors and clinical manifestations among local populations are needed to develop effective preventative strategies and facilitate appropriate and timely diagnosis.

Indexed as

RickettsiaRickettsia InfectionsAfrica South of the SaharaAnimalsHumansRisk FactorsTick-Borne DiseasesTicksAfrican tick bite feverone healthRickettsiasurveillancetick‐borne diseaseticks

Identifiers

PMID38813598
PMCPMC11216893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.