Evidence map›Paper›PMID 38813514›Full record

ArticleTurkish journal of medical sciences2023

Cochlear pathology in preeclamptic rats: protective effects of vitamin D and magnesium sulfate.

Mustafa Altintaş, Enis Hidişoğlu, Alexandra Cernomorcenco, Nuray Ensari, Didem Nevreste Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyigör, Züleyha Dilek Gülmez, Erdoğan Bulut, Serap Şirvanci and 1 more

Abstract read
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In one paragraph

Article in Turkish journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Levels of 25-hydroxyvitamin DFrontiers in neurology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mustafa AltintaşDepartment of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye.ORCID https://orcid.org/0000-0001-7436-2862
Enis HidişoğluDepartment of Drug Science and Technology, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0002-1729-1209
Alexandra CernomorcencoDepartment of Histology and Embryology, Akdeniz University Faculty of Medicine, Antalya, Turkiye.ORCID https://orcid.org/0000-0003-3882-426X
Nuray EnsariDepartment of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye.ORCID https://orcid.org/0000-0002-3373-9173
Didem Nevreste Sonbay YilmazDepartment of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye.ORCID https://orcid.org/0000-0002-6018-7693
Özer Erdem GürDepartment of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye.ORCID https://orcid.org/0000-0002-2846-4136
Hülya EyigörDepartment of Otorhinolaryngology, Antalya Training and Research Hospital, University of Health Science, Antalya, Turkiye.ORCID https://orcid.org/0000-0001-5317-431X
Züleyha Dilek GülmezDepartment of Audiology, Faculty of Health Sciences, Istanbul University-Cerrahpasa, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-8387-4181
Erdoğan BulutDepartment of Audiology, Faculty of Health Sciences, Trakya University, Edirne, Turkiye.ORCID https://orcid.org/0000-0003-2036-6870
Serap ŞirvanciDepartment of Histology and Embryology, Marmara University, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-7683-4587
Selahattin KumruDepartment of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University, Antalya, Turkiye.ORCID https://orcid.org/0000-0001-6615-7666

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, we observed significant beneficial effects of Vit D supplementation at 14.5 and 19.5 dpc in terms of BP (p < 0.05), EW (p < 0.001), and cochlear degeneration compared to the PE group. In the PEM group, BP (p < 0.05) and cochlear degeneration nearly reached the level found in the sham group. However, although the EW was statistically different in the PE group, it did not reach sham group levels. We also observed that BP returned to sham level (p < 0.01) and noticed significant increases in the EW (p < 0.0001) and ES (p = 0.017) in the PEMV group compared to the PE group. According to the scanning electron microscope results, combined administration of VitD and MgSO Conclusion: The administration of Vit D and MgSO

Indexed as

CochleaMagnesium SulfatePre-EclampsiaVitamin DAnimalsDisease Models, AnimalFemalePregnancyRatsRats, Sprague-DawleyMagnesium SulfateVitamin Dcochlear degenerationembryonic survivalembryonic weightmagnesium sulfatePreeclampsiavitamin D

Identifiers

PMID38813514
PMCPMC10760567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.