Evidence map›Paper›PMID 38813443›Full record

ReviewEClinicalMedicine2024

Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis.

Jennifer Dunne, Damien Foo, Berihun A Dachew, Bereket Duko, Amanuel T Gebremedhin, Sylvester D Nyadanu, Gavin Pereira, Gizachew A Tessema

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Baicalin alleviates HScientific reports · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. "Unraveling the Clot-Miscarriage Nexus: Mechanisms, Management, and Future Directions in Thrombosis-Related Recurrent Pregnancy Loss".Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer DunneCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Damien FooCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Berihun A DachewCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Bereket DukoCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Amanuel T GebremedhinCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Sylvester D NyadanuCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Gavin PereiraCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.
Gizachew A TessemaCurtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, Western Australia, 6102, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spontaneous and induced abortions are common outcomes of pregnancy. There is inconsistent evidence of an association between early pregnancy loss and subsequent diabetic and hypertensive disorders in women. This systematic review and meta-analysis evaluated evidence on the risk of the subsequent development of pregnancy and non-pregnancy related diabetic and hypertensive disorders in women who experienced an early pregnancy loss. Methods: Systematic searches were conducted in seven electronic databases (CINAHL Plus, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, and Web of Science) from inception to 22nd December 2023. Studies were included if they reported an exposure of spontaneous abortion (SAB), induced abortion (IA) or recurrent pregnancy loss (RPL) with an outcome of gestational diabetes mellitus, pre-eclampsia, gestational hypertension, and non-pregnancy related diabetic and hypertensive disorders. Risk of bias was assessed using Risk of Bias Instrument for Non-Randomized Studies of Exposures (ROBINS-E). Random effects meta-analysis was used to pool odds of developing diabetic and hypertensive disorders following an early pregnancy loss. This study is registered with PROSPERO (CRD42022327689). Findings: Of 20,176 records, 60 unique articles were identified for full-text review and 52 met the inclusion criteria, representing a total population of 4,132,895 women from 22 countries. Thirty-five studies were suitable for meta-analysis, resulting in a pooled odds ratio (OR) of 1.44 (95% confidence interval (CI) 1.23-1.68) for gestational diabetes mellitus following a prior SAB and a pooled OR of 1.06 (95% CI 0.90-1.26) for pre-eclampsia following a prior SAB. RPL increased the odds of developing pre-eclampsia (OR 1.37 95% CI 1.05-1.79). There was no association between IA and diabetic and hypertensive disorders. Interpretation: A prior SAB was associated with increased odds of gestational diabetes mellitus, but not pre-eclampsia. However, women who experienced RPL had an increased risk of subsequent pre-eclampsia. Future research is required to establish evidence for an association between early pregnancy loss with non-pregnancy related diabetic and hypertensive disorders. Funding: National Health and Medical Research Council.

Indexed as

AbortionDiabetesHypertensionMiscarriagePre-eclampsia

Identifiers

PMID38813443
PMCPMC11133813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.