Evidence map›Paper›PMID 38813168›Full record

ArticleHeliyon2024

Macroenzymes as a reason for aminotransferases flare in cystic fibrosis patients on CFTR modulators therapy - Report of three cases.

Marek Woynarowski, Ewa Sapiejka, Maria Jóźwiak, Justyna Milczewska, Katarzyna Zybert, Adam Krusiński, Jan Siwiec, Aldona Wierzbicka-Rucińska

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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marek WoynarowskiCollegium Medicum, Jan Kochanowski University, Al. IX Wieków Kielc 19A, 25-516, Kielce, Poland.
Ewa SapiejkaDepartment of Paediatrics and Cystic Fibrosis, Paediatric Hospital Polanki, Polanki 119, 80-308, Gdańsk, Poland.
Maria JóźwiakDepartment of Paediatrics and Cystic Fibrosis, Paediatric Hospital Polanki, Polanki 119, 80-308, Gdańsk, Poland.
Justyna MilczewskaCystic Fibrosis Centre, Paediatric Hospital, Dziekanów Leśny, Marii Konopnickiej 65, 05-092, Łomianki, Poland.
Katarzyna ZybertCystic Fibrosis Centre, Paediatric Hospital, Dziekanów Leśny, Marii Konopnickiej 65, 05-092, Łomianki, Poland.
Adam KrusińskiDepartment of Pulmonology, Oncology and Allergology, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland.
Jan SiwiecDepartment of Pulmonology, Oncology and Allergology, Medical University of Lublin, Jaczewskiego 8, 20-954, Lublin, Poland.
Aldona Wierzbicka-RucińskaDepartment of Biochemistry, Radioimmunology and Experimental Medicine, Children's Health Memorial Institute, Al. Dzieci Polskich 20, 04-730, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been shown that macro-ALT/macro-AST cause false increase of ALT/AST activity in standard laboratory testing. This short communication presents a group of cystic fibrosis subjects who developed aminotranferases flare a few months after initiation of CFTR modulators therapy. Patients did not present any clinical signs or symptoms of liver failure and differential examination did not show any underlying liver disease. All patients tested positive for macro-ALT and macro-AST. Despite increased and fluctuating ALT/AST activity in standard tests patients restarted CFTR modulators therapy with good clinical effect and do not present any other than hypertransaminasemia signs or symptoms of progressing liver disease. Our data shows that ALT/AST flare during CFTR modulators therapy may be related to macro-ALT/macro-AST, thus patients with high ALT/AST during CFTR modulators therapy should be tested for macro-ALT/macro-AST.

Indexed as

CFTR modulatorsDrug induced liver injuryHepatotoxicityMacro-ALTMacro-AST

Identifiers

PMID38813168
PMCPMC11133693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.