Evidence map›Paper›PMID 38813118›Full record

ArticleBritish journal of neuroscience nursing2023

Cost-effectiveness of Levodopa-Carbidopa Intestinal Gel in treating people with Advanced Parkinson's disease.

Sonia Raj, Rekha Sarvankar, Luís Filipe, Valerio Benedetto, Nicola Mason, Jennifer Dawber, James Hill, Andrew Clegg

Abstract read
In one paragraph

Article in British journal of neuroscience nursing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonia RajLancashire Teaching Hospitals NHS Foundation Trust.
Rekha SarvankarLancashire Teaching Hospitals NHS Foundation Trust.
Luís FilipeFaculty of Health and Medicine, Lancaster University.
Valerio BenedettoNIHR Applied Research Collaboration North West Coast (ARC NWC), Methodological Innovation, Development, Adaptation and Support (MIDAS) Theme.
Nicola MasonLancashire Teaching Hospitals NHS Foundation Trust.
Jennifer DawberLancashire Teaching Hospitals NHS Foundation Trust.
James HillNIHR Applied Research Collaboration North West Coast (ARC NWC), Methodological Innovation, Development, Adaptation and Support (MIDAS) Theme.
Andrew CleggNIHR Applied Research Collaboration North West Coast (ARC NWC), Methodological Innovation, Development, Adaptation and Support (MIDAS) Theme.

Funding

Department of Health NIHR200182
6 · The paper itself

Abstract

Advanced Parkinson's disease affects patients with existing Parkinson's disease by further deteriorating their physical and cognitive functions. In this commentary we critically assess an economic evaluation which compared the cost-effectiveness of levodopa/carbidopa intestinal gel against standard of care in treating patients with Advanced Parkinson's disease. While the economic evaluation indicated that levodopa/carbidopa intestinal gel could be cost-effective within the UK parameters, we highlight important limitations related to its design, modelling and analysis. Future research should consider the incorporation of a separate arm dedicated to the re-infusion of apomorphine on eligible Advanced Parkinson's disease patients, a wider set of levodopa/carbidopa intestinal gel adverse events and related costs, and a sub-group analysis on different socio-economic strata.

Indexed as

Advanced Parkinson’s diseasecost-effectivenesscostseconomic evaluationlevodopa/carbidopa intestinal gel

Identifiers

PMID38813118
PMCPMC7616015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.