Evidence map›Paper›PMID 38813113›Full record

ArticleNeuro-oncology advances

A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma.

Martha I Betancur, Ayden Case, Ekaterina Ilich, Nalini Mehta, Sean Meehan, Sabrina Pogrebivsky, Stephen T Keir, Kevin Stevenson, Barun Brahma, Simon Gregory and 4 more

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In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martha I BetancurDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-3082-1235
Ayden CaseDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Ekaterina IlichDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Nalini MehtaDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Sean MeehanDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Sabrina PogrebivskyDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Stephen T KeirDepartment of Neurosurgery, Duke University, Durham, North Carolina, USA.
Kevin StevensonMolecular Physiology Institute, Duke University, Durham, North Carolina, USA.
Barun BrahmaDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Simon GregoryMolecular Physiology Institute, Duke University, Durham, North Carolina, USA.
Wei ChenCenter for Genomic and Computational Biology, Duke University, Durham, Georgia, USA.
David M AshleyDepartment of Neurosurgery, Duke University, Durham, North Carolina, USA.
Ravi BellamkondaDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Nassir MokarramDepartment of Neurosurgery, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-5828-7644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A major hurdle to effectively treating glioblastoma (GBM) patients is the lack of longitudinal information about tumor progression, evolution, and treatment response. Methods: In this study, we report the use of a neural tract-inspired conduit containing aligned polymeric nanofibers (i.e., an aligned nanofiber device) to enable on-demand access to GBM tumors in 2 rodent models. Depending on the experiment, a humanized U87MG xenograft and/or F98-GFP+ syngeneic rat tumor model was chosen to test the safety and functionality of the device in providing continuous sampling access to the tumor and its microenvironment. Results: The aligned nanofiber device was safe and provided a high quantity of quality genomic materials suitable for omics analyses and yielded a sufficient number of live cells for Conclusions: The results establish the potential of this neural tract-inspired, aligned nanofiber device as an on-demand, safe, and minimally invasive access point, thus enabling rapid, high-throughput, longitudinal assessment of tumor and its microenvironment, ultimately leading to more informed clinical treatment strategies.

Indexed as

glioblastomaon-demand biopsytumor microenvironment

Identifiers

PMID38813113
PMCPMC11135361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.