ArticleTurkish journal of medical sciences2023
Curcumin promotes skin wound healing by activating Nrf2 signaling pathways and inducing apoptosis in mice.
Article in Turkish journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Healing potential of curcumin gel in experimental wounds infected with resistant Pseudomonas aeruginosa: a comparative study with silver sulfadiazine.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Pharmacological evaluation of curcumin nanosponges enriched with vitamin E: a multifunctional cosmeceutical cream for skin protection and regeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Efficacy and Mechanism of Silymarin Extract for Deep Second-Degree Burns in Rats.Chinese journal of integrative medicine · 2026Article
- Mussel Adhesive Protein/Hyaluronic Acid Hydrogels for EGF Delivery and MRSA-Infected Diabetic Wound Repair.Gels (Basel, Switzerland) · 2026Article
- Natural Extracts in Skin Repair and Wound Healing: Phytochemical Mechanisms and Dermopharmaceutical Perspectives.Molecules (Basel, Switzerland) · 2026Review
- A Scoping Review of Clinical Trials on the Efficacy of Curcumin and Its Formulations for Wound Healing.Journal of cosmetic dermatology · 2025Article
- Curcumin-Loaded Drug Delivery Systems for Acute and Chronic Wound Management: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2025Article
- A Natural Latex-Based Smart Dressing for Curcumin Delivery Combined with LED Phototherapy in Diabetic Foot Ulcers: A Pilot Clinical Study.Pharmaceutics · 2025Article
- Reactive Oxygen Species and Antioxidants in Wound Healing: Mechanisms and Therapeutic Potential.International wound journal · 2025Review
- Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress.Frontiers in cell and developmental biology · 2025Review
- Treatment of diabetic wound based on hypoglycemic and antioxidant.Frontiers in bioengineering and biotechnology · 2025Review
- Curcumin: a potential anti-photoaging agent.Frontiers in pharmacology · 2025Review
- Bibliometric Analysis of Curcumin Based on CiteSpace: Landscapes, Hotspots, and Frontiers.Drug design, development and therapy · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/aim: Curcumin may have potential as a therapy for wound healing, but the underlying mechanism remains unclear. It is not known whether curcumin can promote wound healing by activating Nrf2 signaling pathway and inducing apoptosis. This study determined the role of Nrf2 signaling pathway and apoptosis in curcumin-promoting skin wound healing. Materials and methods: The full-thickness skin defect model of mice was made and randomly divided into a control group and a curcumin group. The mice in the curcumin group and in the control group received respectively a daily topical treatment of Vaseline cream with or without 5 mg curcumin. The wound healing of mice was observed daily. The mice in two groups were killed respectively on postinjury days 3, 7, and 14, and the wound tissues were collected, with 5 mice in each group. Pathological change and formation of collagen fibers were observed by HE and Masson staining respectively. The expression of caspase-3 was observed by immunohistochemistry. Western blot was used to examine the protein levels of Nrf2 and HO-1, and ELISA assay and colorimetry assay were used to check the contents of ROS, MDA, SOD, and GSH. Results: The wound healing rates of curcumin group were higher than those of control group (p < 0.05), and the pathological changes were also significantly better than those in the control group (p < 0.05). Collagen fiber synthesis in curcumin group was higher than that in control group (p < 0.05). Moreover, the expression of caspase-3 in curcumin group was higher than that in control group on 7th day post wound (p < 0.05). Furthermore, the levels of ROS and MDA in curcumin were lower than those in control group (p < 0.05), and the level of Nrf2, HO-1, SOD and GSH were higher than those in control group (p < 0.05). Conclusion: Curcumin improves skin wound healing by activating the Nrf2 signaling pathway and inducing apoptosis in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.