Evidence map›Paper›PMID 38812763›Full record

ArticleActa medica Philippina2024

Virgin Coconut Oil as Adjunctive Therapy for Hospitalized COVID-19 Patients in a Tertiary Referral Hospital: A Randomized Controlled Trial.

Marissa M Alejandria, Leslie Michelle M Dalmacio, Fresthel Monica M Climacosa, Carol Stephanie C Tan-Lim, Mark Joseph M Abaca, Maria Llaine J Callanta, Maria Elizabeth P Mercado

Abstract read
In one paragraph

Article in Acta medica Philippina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marissa M AlejandriaDepartment of Medicine, Philippine General Hospital, University of the Philippines Manila.
Leslie Michelle M DalmacioDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila.
Fresthel Monica M ClimacosaDepartment of Medical Microbiology, College of Public Health, University of the Philippines Manila.
Carol Stephanie C Tan-LimDepartment of Clinical Epidemiology, College of Medicine, University of the Philippines Manila.
Mark Joseph M AbacaDepartment of Medicine, Philippine General Hospital, University of the Philippines Manila.
Maria Llaine J CallantaDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila.
Maria Elizabeth P MercadoDepartment of Clinical Epidemiology, Faculty of Medicine and Surgery, University of Santo Tomas.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Virgin coconut oil (VCO) has anti-viral and anti-inflammatory properties, making it a potential therapeutic candidate against COVID-19 infection. Objective: To determine the efficacy and safety of VCO as adjunctive therapy for hospitalized patients with COVID-19. Methods: We conducted a randomized, open-label controlled trial involving laboratory-confirmed COVID-19 patients admitted at the Philippine General Hospital. The study participants were randomized to the intervention group who received virgin coconut oil with local standard of care, or to the control group who received local standard of care alone. Results: We enrolled 39 participants into the VCO group and 38 participants into the control group. Significantly fewer participants in the VCO group had abnormal CRP levels at the end of treatment compared to control. (relative risk [RR] 0.75, 95% confidence interval [CI] 0.58 to 0.95; Conclusion: This clinical trial on hospitalized patients showed significant benefit in CRP levels of participants given VCO compared to control. There was no significant benefit in the use of VCO as adjunctive therapy in reducing duration of hospital stay. Larger studies are needed to conclusively demonstrate the effect of VCO on other clinical outcomes and inflammatory markers.

Indexed as

clinical trialCOVID-19virgin coconut oil

Identifiers

PMID38812763
PMCPMC11132283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.