ReviewTouchREVIEWS in endocrinology2024
The Placental Role in Gestational Diabetes Mellitus: A Molecular Perspective.
Review in TouchREVIEWS in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07446205 (Poi for Mama), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Influence of maternal diabetes during pregnancy on ultrasound-measured fetal epicardial fat thickness: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Cellular and Molecular Pathophysiology of Gestational Diabetes.International journal of molecular sciences · 2024Pooled it
- Early characterization of pregnancy glycemic traits in gestational diabetes mellitus by plasma cell-free mRNA and non-coding RNA.Epigenetics · 2026Article
- Evaluation of fetal frontal lobe development and Evans index in pregnancies complicated by gestational diabetes mellitus: prospective comparative observational study.BMC pregnancy and childbirth · 2026Observational
- Marked Third-Trimester Placental Thickening Is Associated with Maternal Infectious, Hormonal, and Metabolic Burden: A Matched Case-Control Study.Journal of clinical medicine · 2026Article
- Altered Placental Ezrin Expression in Gestational Diabetes Mellitus: An Immunohistochemical and Bioinformatic Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Dysregulated differentiation kinetics underlie the essential role of DNA damage repair in placental development.Nature communications · 2026Article
- Overlap of Gestational Diabetes Mellitus and Pre-eclampsia: A Scoping Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.Scientific reports · 2026Article
- Emerging Insights into the Liver-Pancreas Axis: A Central Hub in the Pathogenesis of Diabetes and Metabolic Diseases.Biomolecules · 2026Review
- Placental toxicity of alternative plasticizers: Current knowledge and future directions.Reproductive toxicology (Elmsford, N.Y.) · 2026Review
- Abnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus.International journal of molecular sciences · 2026Review
- Special Issue "Molecular Insight into Gestational Diabetes Mellitus".International journal of molecular sciences · 2026Article
- Fractalkine (Chemokine CX3CL1) Signaling During Placentation and Placental Function.International journal of molecular sciences · 2026Review
- Immune dysregulation in gestational diabetes mellitus: placental downregulation of CXCL9 and IL1RL1 and altered immune cell infiltration.Frontiers in cell and developmental biology · 2026Article
- Gestational diabetes and its influence on early neurodevelopment in infants: a retrospective analysis.Frontiers in pediatrics · 2026Article
- Research progress of cerebroplacental ratio in obstetric complications.Frontiers in medicine · 2026Review
- Placental Igf1 overexpression sex-specifically impacts mouse placenta structure, altering offspring striatal development and behavior.Experimental neurology · 2025Article
- Association Between the Lifestyle Inflammation Score and Gestational Diabetes Mellitus and Postpartum Glucose Metabolism Alterations.Nutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose to the foetus. These metabolic modifications develop what is known as physiological insulin resistance. When this process is altered, however, gestational diabetes mellitus (GDM) occurs. GDM is a multifactorial disease, and genetic and environmental factors play a crucial role in its aetiopathogenesis. GDM has been linked to both macroscopic and molecular alterations in placental tissues that affect placental physiology. This review summarizes the role of the placenta in the development of GDM from a molecular perspective, including hormonal and pro-inflammatory changes. Inflammation and hormonal imbalance, the characteristics dominating the GDM microenvironment, are responsible for placental changes in size and vascularity, leading to dysregulation in maternal and foetal circulations and to complications in the newborn. In conclusion, since the hormonal mechanisms operating in GDM have not been fully elucidated, more research should be done to improve the quality of life of patients with GDM and their future children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.