Evidence map›Paper›PMID 38812639›Full record

ArticleTurkish journal of medical sciences2024

Diurnal rhythm of urinary aquaporin-2 in children with primary monosymptomatic nocturnal enuresis.

Nehal Abdelhamid, Mohamed A Abd Almawla, Aliaa A Wahby, Mervat Ismail, Hani Abdelsalam Elmikaty, Hanan M Hamed, Ingy Ashmawy, Batoul Mohamed Abdelraoaf, Enas Mokhtar Abdelhamid, Hassan M Salam

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Article in Turkish journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Nehal AbdelhamidDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0002-0002-5382-2193
Mohamed A Abd AlmawlaDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0001-7678-6175
Aliaa A WahbyDepartment of Clinical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0003-1276-2240
Mervat IsmailDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5150-1572
Hani Abdelsalam ElmikatyDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-1105-2012
Hanan M HamedDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3626-4951
Ingy AshmawyDepartment of Clinical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-6598-3568
Batoul Mohamed AbdelraoafDepartments of Pediatrics, Ainshams University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-8116-7301
Enas Mokhtar AbdelhamidDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-5561-2157
Hassan M SalamDepartments of Pediatrics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.ORCID https://orcid.org/0000-0002-9466-3926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Nocturnal enuresis can be frustrating for children and their families as the child ages. Our aim is to evaluate urine aquaporin 2 (AQP-2) as a noninvasive biomarker of water balance in children with primary monosymptomatic nocturnal enuresis (PMNE). Material and methods: The study included 90 children; sixty-eight children suffering from PMNE aged (9.57 ± 2.16) years and 22 healthy children with good toilet control, matched sex and age. All enuretic children were subjected to complete history taking, clinical evaluation, and bed wetting diary. Serum arginine vasopressin (AVP) and urine AQP-2 were tested in the morning (at 9-11 am) and evening (at 9-11 pm). Blood urea, creatinine, Na, glucose, urine osmolality, Ca/Cr, Alb/Cr and specific gravity were tested simultaneously. Results: Serum AVP, urine AQP-2, and urine osmolality were statistically lower in patients than controls. Patients had a significantly lower level of night serum AVP concentrations, urine AQP-2, and urine osmolality than the corresponding morning level. Urine AQP-2 was significantly correlated with urine osmolality (p < 0.05). AQP-2 had a sensitivity of 90% and a specificity of 70%. However, no statistically significant correlation was found between serum AVP and urine AQP-2. Conclusion: Primary monosymptomatic nocturnal enuresis in children could be associated with reduction of urine excretion of AQP-2 at night. Urine AQP-2 is significantly correlated with urine osmolality. Therefore, it may be a noninvasive biomarker of hydration status in children with PMNE, with good sensitivity and specificity.

Indexed as

Aquaporin 2BiomarkersCircadian RhythmNocturnal EnuresisAdolescentArginine VasopressinCase-Control StudiesChildFemaleHumansMaleOsmolar ConcentrationAQP2 protein, humanAquaporin 2Arginine VasopressinBiomarkersAquaporin 2nocturnal enuresisvasopressin

Identifiers

PMID38812639
PMCPMC11031170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.