Evidence map›Paper›PMID 38812520›Full record

ArticleFrontiers in immunology2024

Tissue-specific sex differences in pediatric and adult immune cell composition and function.

Mahina Tabassum Mitul, Jenna M Kastenschmidt, Suhas Sureshchandra, Zachary W Wagoner, Andrew M Sorn, David R Mcllwain, Jenny E Hernandez-Davies, Aarti Jain, Rafael de Assis, Douglas Trask and 2 more

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Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mahina Tabassum MitulDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Jenna M KastenschmidtDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Suhas SureshchandraDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Zachary W WagonerDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Andrew M SornDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
David R McllwainDepartment of Microbiology and Immunology, Reno School of Medicine, University of Nevada, Reno, NV, United States.
Jenny E Hernandez-DaviesDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Aarti JainDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Rafael de AssisDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Douglas TraskDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, United States.
D Huw DaviesDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.
Lisa E WagarDepartment of Physiology & Biophysics, University of California, Irvine, Irvine, CA, United States.

Funding

Investigating protective adaptive immune responses to influenza antigens using human tonsil organoidsR01AI173023 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lisa Wagar · 2023 to 2026
$2.5M
Immunology Research Training GrantT32AI177324 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Eric Pearlman · 2023 to 2026
$735k
Bill & Melinda Gates Foundation INV-004892NIAID NIH HHS R01 AI173023NIAID NIH HHS T32 AI177324
6 · The paper itself

Abstract

Sex-based differences in immune cell composition and function can contribute to distinct adaptive immune responses. Prior work has quantified these differences in peripheral blood, but little is known about sex differences within human lymphoid tissues. Here, we characterized the composition and phenotypes of adaptive immune cells from male and female ex vivo tonsils and evaluated their responses to influenza antigens using an immune organoid approach. In a pediatric cohort, female tonsils had more memory B cells compared to male tonsils direct ex vivo and after stimulation with live-attenuated but not inactivated vaccine, produced higher influenza-specific antibody responses. Sex biases were also observed in adult tonsils but were different from those measured in children. Analysis of peripheral blood immune cells from

Indexed as

Palatine TonsilAdolescentAdultAntibodies, ViralB-LymphocytesCD4-Positive T-LymphocytesChildChild, PreschoolFemaleHumansImmunologic MemoryInfluenza, HumanInfluenza VaccinesMaleMemory B CellsOrgan SpecificityAntibodies, ViralInfluenza Vaccinesadaptive immunityinfluenza vaccinepediatric immunitysex differencestonsil organoids

Identifiers

PMID38812520
PMCPMC11133680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.