Evidence map›Paper›PMID 38812477›Full record

ArticleEuropean heart journal open2024

Medical treatment of heart failure with renin-angiotensin-aldosterone system inhibitors and beta-blockers in aortic stenosis: association with long-term outcome after aortic valve replacement.

Johan Hopfgarten, Stefan James, Lars Lindhagen, Tomasz Baron, Elisabeth Ståhle, Christina Christersson

Abstract read
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johan HopfgartenDepartment of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85, Uppsala, Sweden.ORCID https://orcid.org/0009-0005-4322-7664
Stefan JamesDepartment of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-4413-9736
Lars LindhagenUppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Tomasz BaronDepartment of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-8290-557X
Elisabeth StåhleDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Christina ChristerssonDepartment of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-9116-8084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: There is a lack of robust data on the optimal medical treatment of heart failure in patients with severe aortic stenosis, with no randomized controlled trials guiding treatment. The study aimed to study the association between exposure to renin-angiotensin-aldosterone system (RAS) inhibitors or beta-blockers and outcome after aortic valve replacement in patients with aortic stenosis and heart failure. Methods and results: The study included all patients with heart failure undergoing aortic valve replacement for aortic stenosis in Sweden between 2008 and 2016 ( Conclusion: The RAS inhibition was associated with a lower all-cause mortality after valve replacement in patients with both reduced and preserved LV-EF. Beta-blockade was associated with lower all-cause mortality only in patients with reduced LV-EF.

Indexed as

Aortic stenosisAortic valve replacementHeart failure

Identifiers

PMID38812477
PMCPMC11135942

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.