Evidence map›Paper›PMID 38812118›Full record

ArticleExperimental physiology2024

SRS 16-86 promotes diabetic nephropathy recovery by regulating ferroptosis.

Yingchun Qiao, Chao Sun, Shunli Kan, Lu He, Yawen Wang, Huajun Gao, Yingying Zhang, You Cheng, Shuai Wang, Long Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yingchun QiaoNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Chao SunInternational Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.ORCID 0009-0002-6172-4152
Shunli KanDepartment of Spine Surgery, Tianjin Union Medical Center, Tianjin, China.
Lu HeNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Yawen WangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Huajun GaoNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Yingying ZhangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
You ChengNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Shuai WangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Long ZhaoInternational Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.
Wenyan NiuNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Department of Clinical Laboratory, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Funding

Funding of Tianjin Educational Committee 2022KJ242Funding of Tianjin Health Research Project KJ20061Funding of Tianjin Health Research Project ZC20225Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital 2018ZDKF10Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital 2019ZDKF02Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital 2019ZDKF08
6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM), and cell death plays an important role. Ferroptosis is a recently discovered type of iron-dependent cell death and one that is different from other kinds of cell death including apoptosis and necrosis. However, ferroptosis has not been described in the context of DN. This study explored the role of ferroptosis in DN pathophysiology and aimed to confirm the efficacy of the ferroptosis inhibitor SRS 16-86 on DN. Streptozotocin injection was used to establish the DM and DN animal models. To investigate the presence or occurrence of ferroptosis in DN, we assessed the concentrations of iron, reactive oxygen species and specific markers associated with ferroptosis in a rat model of DN. Additionally, we performed haematoxylin-eosin staining, blood biochemistry, urine biochemistry and kidney function analysis to evaluate the efficacy of the ferroptosis inhibitor SRS 16-86 in ameliorating DN. We found that SRS 16-86 could improve the recovery of renal function after DN by upregulating glutathione peroxidase 4, glutathione and system x

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesFerroptosisRats, Sprague-DawleyAnimalsIronKidneyLipid PeroxidationMaleRatsReactive Oxygen SpeciesIronReactive Oxygen Speciesdiabetic nephropathyferroptosisferroptosis inhibitor

Identifiers

PMID38812118
PMCPMC11215488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.