SynthesisJournal of orthopaedic surgery and research2024
Risk factors of chronic postoperative pain after total knee arthroplasty: a systematic review.
Synthesis in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07727551 (Enhancing Functional Outcomes in Total Knee Arthroplasty), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Functional Outcomes in Total Knee Arthroplasty: the Role of Preoperative Genicular Radiofrequency
Who cites it
14 citing papers in PubMed.
- Impact of upper-limb aerobic exercise on the prevention of chronic postsurgical pain after total knee arthroplasty: a randomized controlled trial.BMC research notes · 2026Trial
- Individualizing Perioperative Analgesia: Patient-Specific Determinants of Postoperative Pain and Opioid-Related Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Robotic-assisted total knee arthroplasty: accuracy, clinical outcomes, complications, learning curve and cost-effectiveness: a critical clinical review.Journal of robotic surgery · 2026Review
- Chronic Pain and Stiffness After Total Knee Arthroplasty: A Comprehensive, Phenotype-Based Review of Mechanisms, Diagnosis and Management.Journal of clinical medicine · 2026Review
- Article
- Why sleep matters in chronic pain: evidence across the lifespan.EBioMedicine · 2026Review
- Association of preoperative corticosteroids with persistent opioid requirements following total knee arthroplasty: an exploratory population-based cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Association of Preoperative Systemic Inflammatory Indices with Early Postoperative Pain and Function After Total Knee Arthroplasty: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Association of Morbid Obesity (BMI ≥40) With Postoperative Complications and Pain After Insertional Achilles Tendinopathy Achilles Splitting Surgical Treatment.Foot & ankle orthopaedics · 2026Article
- Opioid Consumption After Laparoscopic Radical Nephrectomy in Early Postoperative Recovery Phase: A Retrospective Cohort Study.Acta anaesthesiologica Scandinavica · 2026Article
- Early Postoperative Pain and Its Risk Factors in Patients Undergoing Total Knee Arthroplasty Under the ERAS Protocol.Journal of pain research · 2026Article
- Association between BDNF/CB1R expression and postoperative pain and recovery in patients with preoperative sleep disorders.BMC anesthesiology · 2025Article
- Construction and validation of nomogram model for chronic postsurgical pain in patients after total knee arthroplasty: A retrospective study.Pakistan journal of medical sciences · 2025Article
- Chronic Post-Surgical Pain After Hip and Knee Arthroplasty: An Update on Mechanisms, Risk Factors, and Interventional Treatment Modalities.Journal of pain research · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThere is a lack of relevant studies to grade the evidence on the risk factors of chronic pain after total knee arthroplasty (TKA), and only quantitative methods are used for systematic evaluation. The review aimed to systematically identify risk factors of chronic postoperative pain following TKA and to evaluate the strength of the evidence underlying these correlations.
methodsPubMed, Web of Science, Cochrane Library, Embase, and CINAHL databases were searched from initiation to September 2023. Cohort studies, case-control studies, and cross-sectional studies involving patients undergoing total knee replacement were included. A semi-quantitative approach was used to grade the strength of the evidence-based on the number of investigations, the quality of the studies, and the consistency of the associations reported by the studies.
resultsThirty-two articles involving 18,792 patients were included in the final systematic review. Ten variables were found to be strongly associated with postoperative pain, including Age, body mass index (BMI), comorbidities condition, preoperative pain, chronic widespread pain, preoperative adverse health beliefs, preoperative sleep disorders, central sensitization, preoperative anxiety, and preoperative function. Sixteen factors were identified as inconclusive evidence.
conclusionsThis systematic review clarifies which risk factors could be involved in future research on TKA pain management for surgeons and patients. It highlights those factors that have been controversial or weakly correlated, emphasizing the need for further high-quality studies to validate them. Most crucially, it can furnish clinicians with vital information regarding high-risk patients and their clinical attributes, thereby aiding in the development of preventive strategies to mitigate postoperative pain following TKA.
trial registrationThis systematic review has been registered on the PROSPERO platform (CRD42023444097).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.