ArticleHypertension research : official journal of the Japanese Society of Hypertension2024
Associations of maternal liver biomarkers in the first trimester with the risk of hypertensive disorders of pregnancy.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Elevated gamma-glutamyl transferase levels in early pregnancy increase pregnant women's risk of gestational hypertension and preeclampsia.Journal of global health · 2026Article
- The associations of maternal liver biomarkers in different trimesters with birth weight outcomes.Scientific reports · 2026Article
- Elevated maternal serum aminotransferase in early pregnancy associated with early-onset preeclampsia: A cohort study of 116,967 pregnancies in Shanghai, China.BMC pregnancy and childbirth · 2025Article
- Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Development and Validation of a Nomogram for Predicting the Probability of Postpartum Chronic Hypertension in Women With Hypertensive Disorders of Pregnancy: A Multicenter, Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Evolution of reference intervals for renal-hepatic biomarkers and micronutrients in normal pregnancy during Covid-19 pandemic (2021-2022) in some hospitals of Kinshasa, Democratic Republic of the Congo.Practical laboratory medicine · 2025Article
- Positive and linear association of hepatic steatosis index with female infertility in US women: results from the National Health and Nutrition Examination Survey 2013-2018.Frontiers in public health · 2025Article
- Elucidating the role of hepatic enzymes in spontaneous abortion: a Mendelian randomization approach.Frontiers in genetics · 2024Article
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Abstract
This study aimed to evaluate the association between maternal liver biomarkers in early pregnancy and the risk of hypertensive disorders of pregnancy (HDP), as well as to evaluate interaction between liver enzymes and BMI on the development of HDP. Pregnant women in our study were recruited from the Zhoushan Pregnant Women Cohort. Participants who had their first prenatal follow-up and the blood pressure follow-up records, and measured liver biomarkers in the first trimester were eligible for inclusion in the study. A total of 10,610 pregnant women were included in the analysis, and 305 (2.87%) developed the HDP. There were positive associations between AST, GGT, ALP, HSI and SBP, as well as between ALT, GGT, ALP, HSI and DBP. In addition, AST/ALT level was negatively associated with DBP. The highest quartile of GGT, ALP, AST/ALT and HSI were significantly associated with 1.71-fold (95% Cl: 1.23-2.41), 1.53-fold (95% Cl: 1.10-2.14), 0.62-fold (95% Cl: 0.43-0.90) and 1.67-fold (95% Cl: 1.05-2.67) increased risk of HDP, respectively. There was no significant association between ALT, AST and HDP. These associations remained consistent in pregnant women with liver enzymes within the clinical reference range. Besides, we found an interaction between GGT and BMI (P
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