ReviewJournal of sleep research2025
Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?
Review in Journal of sleep research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed.
- Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial.Nature and science of sleep · 2025Trial
- Reduced sensorimotor lactate concentration and improved sleep efficiency following resistance training in older adults.GeroScience · 2026Article
- Toward an idiographic understanding of the role of sleep-mood dynamics in adolescents' internalizing symptoms.JCPP advances · 2026Article
- The Interplay Between Emotion Dysregulation and Repetitive Thoughts in Insomnia Disorder: The Impact of Worry, Rumination and REM Sleep Instability.Journal of sleep research · 2026Article
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- Article
- Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Observational
- Anxiety disorders: a cross-sectional study of clinical and biological associations.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The effect of enhanced external counterpulsation on sleep quality and quality of life in patients with chronic insomnia: study protocol for a randomized controlled trial.BMC psychiatry · 2026Article
- Instability in sleep architecture and intermittent hypoxia underlie cognitive impairment in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Article
- Daytime Performance in Insomnia Patients.Journal of sleep research · 2026Article
- Association between ultra-processed foods intake and sleep quality/quantity in community-dwelling older adults.Sleep & breathing = Schlaf & Atmung · 2026Article
- Influence of Preoperative Cognitive Function, Self-Efficacy, and Postoperative Psychological Counselling on Anxiety and Depression Levels in Patients Undergoing Botulinum Toxin Injections.Actas espanolas de psiquiatria · 2026Article
- Psychological consequences of insufficient sleep in medical students.Discover mental health · 2026Article
- Insomnia disorder.Nature reviews. Disease primers · 2026Review
- Sleep architecture and rapid eye movement sleep without atonia in post-COVID-19 insomnia.Sleep · 2026Article
- The Associations of Maladaptive Personality, Self-Regulation, and Sleep Hygiene with Insomnia Severity: A serial Mediation Model.The Psychiatric quarterly · 2026Article
- A mixed-method process evaluation of guided online cognitive behavioral therapy for insomnia in patients with borderline personality disorder.BMC psychiatry · 2026Article
- Sleep characteristics and risk factors in patients of insomnia comorbid with anxiety.BMC psychology · 2026Article
- Study on diagnostic models for insomnia and gastralgia with Liver-Spleen Disharmony Syndrome based on machine learning.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world-wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders. Persistent hyperarousals at the cognitive, emotional, cortical and/or physiological levels are central to most theories regarding the pathophysiology of insomnia. Of the defining features of insomnia disorder, the discrepancy between minor objective polysomnographic alterations of sleep continuity and substantive subjective impairment in insomnia disorder remains enigmatic. Microstructural alterations, especially in rapid eye movement sleep ("rapid eye movement sleep instability"), might explain this mismatch between subjective and objective findings. As rapid eye movement sleep represents the most highly aroused brain state during sleep, it might be particularly prone to fragmentation in individuals with persistent hyperarousal. In consequence, mentation during rapid eye movement sleep may be toned more as conscious-like wake experience, reflecting pre-sleep concerns. It is suggested that this instability of rapid eye movement sleep is involved in the mismatch between subjective and objective measures of sleep in insomnia disorder. Furthermore, as rapid eye movement sleep has been linked in previous works to emotional processing, rapid eye movement sleep instability could play a central role in the close association between insomnia and depressive and anxiety disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.