Evidence map›Paper›PMID 38811719›Full record

ArticleScientific reports2024

CHOP-mediated IL-23 overexpression does not drive colitis in experimental spondyloarthritis.

Fatemeh Navid, Tejpal Gill, Lilah Fones, Jules D Allbritton-King, Kelly Zhou, Isabel Shen, Jinny Van Doorn, Francesca LiCausi, Antony Cougnoux, Davide Randazzo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatemeh NavidPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA. fatemeh.navid@nih.gov.
Tejpal GillPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Lilah FonesPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Jules D Allbritton-KingClinical and Investigative Orthopedics Surgery Unit, NIAMS, NIH, Bethesda, MD, 20892, USA.
Kelly ZhouPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Isabel ShenPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Jinny Van DoornPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Francesca LiCausiPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.
Antony CougnouxSection on Molecular Dysmorphology, NICHD, NIH, Bethesda, MD, 20892, USA.
Davide RandazzoLight Imaging Section, NIAMS, NIH, Bethesda, MD, 20892, USA.
Stephen R BrooksBiodata Mining and Discovery Section, NIAMS, NIH, Bethesda, MD, 20892, USA.
Robert A ColbertPediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 20892, USA.

Funding

Pathogenic Mechanisms in SpondyloarthritisZIAAR041184 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$47.6M
NIAMS Light Imaging FacilityZICAR041186 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI RANDAZZO, DAVIDE · 2010 to 2025
$18.2M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
NIAMS Intramural Research Program Z01 AR041184NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

HLA-B27 is a major risk factor for spondyloarthritis (SpA), yet the underlying mechanisms remain unclear. HLA-B27 misfolding-induced IL-23, which is mediated by endoplasmic reticulum (ER) stress has been hypothesized to drive SpA pathogenesis. Expression of HLA-B27 and human β

Indexed as

ColitisEndoplasmic Reticulum StressHLA-B27 AntigenSpondylarthritisTranscription Factor CHOPAnimalsColonDisease Models, AnimalHumansInterleukin-17Interleukin-23Interleukin-23 Subunit p19MacrophagesRatsRats, TransgenicDdit3 protein, ratHLA-B27 AntigenInterleukin-17Interleukin-23Interleukin-23 Subunit p19Transcription Factor CHOP

Identifiers

PMID38811719
PMCPMC11137091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.