Evidence map›Paper›PMID 38811718›Full record

ArticlePediatric research2024

Differences in autophagy marker levels at birth in preterm vs. term infants.

Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan Sharma, Martin Röösli, Pablo Sinues, Primo Schär, David Schürmann, Céline Rüttimann and 9 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Noëmi KünstleUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Olga GorlanovaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Andrea MartenUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Loretta MüllerDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pawan SharmaCenter for Translational Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Jane & Leonard Korman Respiratory Institute, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Martin RöösliSwiss Tropical and Public Health Institute, Allschwil, Switzerland and University of Basel, Basel, Switzerland.
Pablo SinuesUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Primo SchärDepartment of Biomedicine, University of Basel, Basel, Switzerland.
David SchürmannDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Céline RüttimannUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Carla Rebeca Da Silva SenaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Uri NahumUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Jakob UsemannUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Ruth SteinbergUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Sophie YammineDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sven SchulzkeUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Philipp LatzinDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Urs FreyUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland. urs.frey@ukbb.ch.ORCID 0000-0003-3773-2822
BILD study group

Funding

E3 ubiquitin ligase RNF145 in airway smooth muscle functions and in asthmaR01HL161205 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Pawan Sharma · 2022 to 2026
$2.4M
NHLBI NIH HHS R01 HL161205
6 · The paper itself

Abstract

backgroundPreterm infants are susceptible to oxidative stress and prone to respiratory diseases. Autophagy is an important defense mechanism against oxidative-stress-induced cell damage and involved in lung development and respiratory morbidity. We hypothesized that autophagy marker levels differ between preterm and term infants.

methodsIn the prospective Basel-Bern Infant Lung Development (BILD) birth cohort we compared cord blood levels of macroautophagy (Beclin-1, LC3B), selective autophagy (p62) and regulation of autophagy (SIRT1) in 64 preterm and 453 term infants.

resultsBeclin-1 and LC3B did not differ between preterm and term infants. However, p62 was higher (0.37, 95% confidence interval (CI) 0.05;0.69 in log2-transformed level, p = 0.025, p

conclusionOur findings suggest differential levels of key autophagy markers between preterm and term infants. This adds to the knowledge of the sparsely studied field of autophagy mechanisms in preterm infants and might be linked to impaired oxidative stress response, preterm birth, impaired lung development and higher susceptibility to respiratory morbidity in preterm infants. IMPACT: To the best of our knowledge, this is the first study to investigate autophagy marker levels between human preterm and term infants in a large population-based sample in cord blood plasma This study demonstrates differential levels of key autophagy markers in preterm compared to term infants and an association with gestational age This may be linked to impaired oxidative stress response or developmental aspects and provide bases for future studies investigating the association with respiratory morbidity.

Indexed as

AutophagyBeclin-1BiomarkersFetal BloodInfant, PrematureMicrotubule-Associated ProteinsSirtuin 1FemaleGestational AgeHumansInfant, NewbornLungMaleOxidative StressProspective StudiesBeclin-1BECN1 protein, humanBiomarkersMAP1LC3B protein, humanMicrotubule-Associated ProteinsSIRT1 protein, humanSirtuin 1

Identifiers

PMID38811718
PMCPMC11521993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.