Evidence map›Paper›PMID 38811666›Full record

ArticleScientific reports2024

A case-control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children.

Meri Mkhitaryan, Tamara Avetisyan, Anna Mkhoyan, Larisa Avetisyan, Konstantin Yenkoyan

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meri MkhitaryanNeuroscience Laboratory, Cobrain Center, Yerevan State Medical University Named After M. Heratsi, 0025, Yerevan, Armenia.
Tamara AvetisyanCobrain Center, Yerevan State Medical University Named After M. Heratsi, 0025, Yerevan, Armenia.
Anna MkhoyanDepartment of Infectious Diseases, Yerevan State Medical University Named After M. Heratsi, 0025, Yerevan, Armenia.
Larisa AvetisyanCobrain Center, Yerevan State Medical University Named After M. Heratsi, 0025, Yerevan, Armenia.
Konstantin YenkoyanNeuroscience Laboratory, Cobrain Center, Yerevan State Medical University Named After M. Heratsi, 0025, Yerevan, Armenia. konstantin.yenkoyan@meduni.am.

Funding

State Committee of Science 24YSMU-CON-I-3A
6 · The paper itself

Abstract

We aimed to investigate the role of pre-, peri- and neonatal risk factors in the development of autism spectrum disorder (ASD) among Armenian children with the goal of detecting and addressing modifiable risk factors to reduce ASD incidence. For this purpose a retrospective case-control study using a random proportional sample of Armenian children with ASD to assess associations between various factors and ASD was conducted. The study was approved by the local ethical committee, and parental written consent was obtained. A total of 168 children with ASD and 329 controls were included in the analysis. Multivariable logistic regression analysis revealed that male gender, maternal weight gain, use of MgB6, self-reported stress during the pregnancy, pregnancy with complications, as well as use of labor-inducing drugs were associated with a significant increase in the odds of ASD, whereas Duphaston use during pregnancy, the longer interpregnancy interval and birth height were associated with decreased odds of ASD. These findings are pertinent as many identified factors may be preventable or modifiable, underscoring the importance of timely and appropriate public health strategies aimed at disease prevention in pregnant women to reduce ASD incidence.

Indexed as

Autism Spectrum DisorderArmeniaCase-Control StudiesChildChild, PreschoolFemaleHumansIncidenceInfant, NewbornMalePregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsRetrospective StudiesRisk FactorsAutism spectrum disorderCase–control studyPregnancyRisk factors

Identifiers

PMID38811666
PMCPMC11137108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.