Evidence map›Paper›PMID 38811604›Full record

ArticleScientific reports2024

Nascent chains derived from a foldable protein sequence interact with specific ribosomal surface sites near the exit tunnel.

Meranda M Masse, Valeria Guzman-Luna, Angela E Varela, Ummay Mahfuza Shapla, Rachel B Hutchinson, Aniruddha Srivastava, Wanting Wei, Andrew M Fuchs, Silvia Cavagnero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meranda M MasseDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Valeria Guzman-LunaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Angela E VarelaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Ummay Mahfuza ShaplaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Rachel B HutchinsonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Aniruddha SrivastavaDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Wanting WeiDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Andrew M FuchsDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Silvia CavagneroDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. cavagnero@chem.wisc.edu.

Funding

Directorate for STEM Education MCB-2124672National Science Foundation CBET-1912259University of Wisconsin-Madison Science and Medicine Graduate Research Scholars FellowshipUniversity of Wisconsin-Madison Straka FellowshipUniversity of Wisconsin-Madison TEAM Science Fellowship
6 · The paper itself

Abstract

In order to become bioactive, proteins must be translated and protected from aggregation during biosynthesis. The ribosome and molecular chaperones play a key role in this process. Ribosome-bound nascent chains (RNCs) of intrinsically disordered proteins and RNCs bearing a signal/arrest sequence are known to interact with ribosomal proteins. However, in the case of RNCs bearing foldable protein sequences, not much information is available on these interactions. Here, via a combination of chemical crosslinking and time-resolved fluorescence-anisotropy, we find that nascent chains of the foldable globin apoHmp

Indexed as

Protein FoldingRibosomal ProteinsRibosomesHumansIntrinsically Disordered ProteinsModels, MolecularMolecular ChaperonesProtein BindingProtein BiosynthesisProtein ConformationIntrinsically Disordered ProteinsMolecular ChaperonesRibosomal Proteins

Identifiers

PMID38811604
PMCPMC11137106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.