ArticleNature communications2024
Stochasticity, determinism, and contingency shape genome evolution of endosymbiotic bacteria.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts.Molecular biology and evolution · 2026Article
- Improvement of Insulin Resistance byMicroorganisms · 2026Article
- Cellular remodeling of ovarian follicular epithelial cells transmits an obligate nutritional endosymbiont in a scale insect.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparative Genomics Reveals Multipartite Genomes Undergoing Loss in the Fungal Endosymbiotic Genus Mycetohabitans.Genome biology and evolution · 2025Article
- Coevolution Dynamics of Beneficial and Pathogenic Microbes in Plant-Microbe Interactions.Biology · 2025Review
- Independent and repeated acquisition ofRoyal Society open science · 2025Article
- Effect of Oceanic Islands on an Insect Symbiont Genome in Transition to a Host-Restricted Lifestyle.Genome biology and evolution · 2025Article
- A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.Signal transduction and targeted therapy · 2024Review
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Authors and funding
7 authors.
Funding
Abstract
Evolution results from the interaction of stochastic and deterministic processes that create a web of historical contingency, shaping gene content and organismal function. To understand the scope of this interaction, we examine the relative contributions of stochasticity, determinism, and contingency in shaping gene inactivation in 34 lineages of endosymbiotic bacteria, Sodalis, found in parasitic lice, Columbicola, that are independently undergoing genome degeneration. Here we show that the process of genome degeneration in this system is largely deterministic: genes involved in amino acid biosynthesis are lost while those involved in providing B-vitamins to the host are retained. In contrast, many genes encoding redundant functions, including components of the respiratory chain and DNA repair pathways, are subject to stochastic loss, yielding historical contingencies that constrain subsequent losses. Thus, while selection results in functional convergence between symbiont lineages, stochastic mutations initiate distinct evolutionary trajectories, generating diverse gene inventories that lack the functional redundancy typically found in free-living relatives.
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