Evidence map›Paper›PMID 38811503›Full record

ArticleDigestive diseases and sciences2024

Utility of the Endoscopic Healing Index in Identifying Active Inflammation in Patients with Crohn's Disease: Real World Data from a Tertiary Center.

Nathaniel A Cohen, Tenzin Choden, Emma C Dyer, Nicole M Garcia, Natalie K Choi, David T Rubin

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathaniel A CohenInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
Tenzin ChodenInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
Emma C DyerInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
Nicole M GarciaInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
Natalie K ChoiInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
David T RubinInflammatory Bowel Disease Center, University of Chicago Medicine, MD 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA. drubin@medicine.bsd.uchicago.edu.ORCID http://orcid.org/0000-0001-5647-1723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Endoscopic Healing Index (EHI) analyzes biomarkers in a patient's peripheral blood to assess mucosal healing. We aimed to characterize the effectiveness of the EHI as a predictor of disease activity in a real world clinical setting.

methodsThis retrospective study looked at patients treated and followed up at the University of Chicago Medicine IBD center who had EHI tests done as part of routine clinical care. The results of the EHI were compared with radiological imaging or endoscopy performed within 3 months of the EHI in order to determine accuracy at diagnosing active inflammation.

resultsFifty-five patients with CD and with an available EHI were included in this study. Four (50%) patients with an EHI of < 20 (n = 8) had evidence of objective inflammation. A cutoff of ≤ 20 had a sensitivity of 89% and specificity of 23.5% for predicting no evidence of any objective inflammation with an AUROC of 0.69. This score had a negative predictive value (NPV) of 50% and positive predictive value (PPV) of 72.3%. A cutoff EHI of 30 tended to classify patients as either having objective evidence of inflammation or not more often than FCAL (Correctly classifying inflammation: 89% vs 64%, respectively; p = 0.32).

conclusionIn this real world analysis, the EHI showed poor predictive value for the absence of active inflammation as assessed by imaging or endoscopy, has limited utility in confirming deep remission and should be used with another objective modality.

Indexed as

Crohn DiseaseAdultBiomarkersEndoscopy, GastrointestinalFemaleHumansIntestinal MucosaMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTertiary Care CentersWound HealingYoung AdultBiomarkersCrohn’s diseaseDisease monitoringMucosal healingReal world evidence

Identifiers

PMID38811503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.