Evidence map›Paper›PMID 38811449›Full record

ArticleMolecular diversity2025

Design, synthesis and inhibitory activity against Candida albicans of a series of derivatives with 5-nitrofuran scaffold.

Jinshuo Zheng, Dongchun Li, Jia Dong, Panchen Wang, Huiling Geng

Abstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinshuo ZhengCollege of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Dongchun LiCollege of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Jia DongCollege of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Panchen WangCollege of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Huiling GengCollege of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100, Shaanxi, China. genghuiling@nwsuaf.edu.cn.

Funding

Key Research and Development Project of Shaanxi Province 2023-YBNY-242National Natural Science Foundation of China No. 31572038
6 · The paper itself

Abstract

The increasing resistance of Candida albicans against the currently available antifungal drugs has exerted enormous damage to human health. To develop novel and efficient antifungal agents with unique structure, a series of derivatives containing 5-nitrofuran scaffold (33 examples) were designed, synthesized, and screened the in vitro antifungal activities. Bioassay results disclosed that 5-nitrofuran derivatives could dramatically inhibit the growth of six strains of Candida albicans, particularly the drug-resistant clinical ones. There were ten kinds of compounds exhibited stronger inhibitory activities against tested fungi than those of fluconazole. For all tested fungi, B5 showed the highest activity with the MIC

Indexed as

Antifungal AgentsCandida albicansDrug DesignNitrofuransCell LineHumansMicrobial Sensitivity TestsReactive Oxygen SpeciesStructure-Activity RelationshipAntifungal AgentsNitrofuransReactive Oxygen Species5-Nitrofuran derivativesAntifungal activityAntifungal mechanismLead compound

Identifiers

PMID38811449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.