Evidence map›Paper›PMID 38811232›Full record

ArticleExperimental animals2024

Relationship between aging and periodontal disease severity in gauge-raised cynomolgus monkeys (Macaca fascicularis).

Takaharu Sone, Motohiro Komaki, Tadashi Sankai, Hiroko Hiramine, Kiyoko Watanabe, Nobushiro Hamada, Toshiro Kodama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental animals, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takaharu SoneDepartment of Oral and Maxillofacial Implantology, Kanagawa Dental University, 3-31-6 Tsuruya, Kanagawa-ku, Yokohama, Kanagawa 221-0835, Japan.
Motohiro KomakiDepartment of Periodontology, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan.
Tadashi SankaiTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, 1-1 Hachimandai, Tsukuba, Ibaraki 305-0843, Japan.
Hiroko HiramineDepartment of General Dentistry, Kanagawa Dental University, Kanagawa Dental University, 3-31-6 Tsuruya, Kanagawa-ku, Yokohama, Kanagawa 221-0835, Japan.
Kiyoko WatanabeDepartment of Liberal Arts Education, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan.
Nobushiro HamadaDepartment of Oral Microbiology, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan.
Toshiro KodamaKanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to evaluate the periodontal disease status in different age groups and clarify the relationship between aging and the severity of periodontal disease. The test animals were cynomolgus monkeys that were born and raised at Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition. The participants were divided into three groups: young (5-10 years old), middle (10-19 years old), and old (≥20 years old). The Plaque Index (PLI), Gingival Index (GI), Probing pocket depth (PPD), and Bleeding on probing (BOP) were used for the periodontal examination. Representative teeth were also examined. Polymerase chain reaction (PCR) was used to identify Porphyromonas macacae in dental plaque. Multiple comparisons and regression analyses were used to analyze the relationship between each age group and each oral examination index. Statistically significant differences were found between the age groups and periodontal examination index. Multiple regression analysis revealed that age was strongly correlated with each oral examination index. Based on these results, oral examinations of cynomolgus monkeys kept in the same environment confirmed an association between aging and periodontal disease severity. Monkeys at this facility are expected to serve as new experimental models for elucidating the mechanisms underlying the progression of age-related periodontal disease.

Indexed as

AgingMacaca fascicularisPeriodontal DiseasesPeriodontal IndexAnimalsDental Plaque IndexDisease Models, AnimalFemaleMaleSeverity of Illness Indexagingcynomolgus monkeysperiodontal disease

Identifiers

PMID38811232
PMCPMC11534493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.