Evidence map›Paper›PMID 38811229›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Primary Adrenal Insufficiency Triggered by Cytomegalovirus Infection after Obinutuzumab Plus Bendamustine Therapy for Follicular Lymphoma.

Takashi Nakamura, Hideki Uryu, Ryutaro Kawashima, Mizuki Ishiguro, Mika Tanizawa, Yasushi Kanazawa, Hiroyuki Yamazaki, Yuichi Yahagi

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takashi NakamuraDepartment of Hematology, Kawaguchi Municipal Medical Center, Japan.
Hideki UryuDepartment of Hematology, Kawaguchi Municipal Medical Center, Japan.
Ryutaro KawashimaDepartment of Endocrinology and Diabetes, Kawaguchi Municipal Medical Center, Japan.
Mizuki IshiguroDepartment of Endocrinology and Diabetes, Kawaguchi Municipal Medical Center, Japan.
Mika TanizawaDepartment of Endocrinology and Diabetes, Kawaguchi Municipal Medical Center, Japan.
Yasushi KanazawaDepartment of Endocrinology and Diabetes, Kawaguchi Municipal Medical Center, Japan.
Hiroyuki YamazakiDepartment of Hematology, Kawaguchi Municipal Medical Center, Japan.
Yuichi YahagiDepartment of Hematology, Kawaguchi Municipal Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 69-year-old man was diagnosed with follicular lymphoma (grade 3A). Obinutuzumab combined with bendamustine (OB) therapy was initiated as salvage chemotherapy. Nausea, abdominal pain, and hyponatremia appeared after six courses of OB therapy; cytomegalovirus (CMV) enteritis with primary adrenal insufficiency (PAI) was a complication. Ganciclovir and hydrocortisone were administered, and the clinical findings improved. PAI caused by CMV infection has mainly been reported in patients with acquired immunodeficiency syndrome. In the present case, the PAI triggered by CMV infection led to immunodeficiency after chemotherapy.

Indexed as

Adrenal InsufficiencyAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCytomegalovirus InfectionsLymphoma, FollicularAgedBendamustine HydrochlorideHumansMaleAntibodies, Monoclonal, HumanizedBendamustine Hydrochlorideobinutuzumabbendamustinecytomegalovirus infectionfollicular lymphomaobinutuzumabprimary adrenal insufficiency

Identifiers

PMID38811229
PMCPMC11802235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.