Evidence map›Paper›PMID 38811218›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction.

Futoshi Eto, Tomohisa Nezu, Hideaki Sakahara, Yumiko Yamamoto, Shiro Aoki, Maiko Shimomura, Shuhei Karakawa, Hirofumi Maruyama

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Futoshi EtoDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Tomohisa NezuDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Hideaki SakaharaDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Yumiko YamamotoDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shiro AokiDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Maiko ShimomuraDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shuhei KarakawaDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Hirofumi MaruyamaDepartment of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 11-year-old boy developed cardioembolic stroke (CES) and cancer therapy-related cardiac dysfunction (CTRCD). He originally developed Ewing sarcoma and was treated with high-dose chemotherapy including doxorubicin. On admission, he had severe aphasia, and magnetic resonance imaging showed occlusion of the left middle cerebral artery M3 segment. Transthoracic echocardiography revealed severe left ventricular dysfunction and a mobile thrombus at the left ventricular apex. Intravenous thrombolysis was administered, and effective recanalization was achieved. The patient did not exhibit any neurological deficits during discharge. Reperfusion therapy for pediatric patients has not yet been established; however, it may be effective for CES secondary to CTRCD.

Indexed as

Antineoplastic AgentsHeart DiseasesIschemic StrokeThrombolytic TherapyVentricular Dysfunction, LeftAdministration, IntravenousChildDoxorubicinFibrinolytic AgentsHumansMaleSarcoma, EwingAntineoplastic AgentsDoxorubicinFibrinolytic Agentsanthracyclinecancer therapy-related cardiac dysfunctionintravenous thrombolysisleft ventricular thrombuspediatric stroketransthoracic echocardiography

Identifiers

PMID38811218
PMCPMC11802214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.