Evidence map›Paper›PMID 38811034›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2024

Breathing new life into the study of COPD with genes identified from genome-wide association studies.

Rhiannon B Werder, Xiaobo Zhou, Michael H Cho, Andrew A Wilson

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026
    Review
  2. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development.American journal of respiratory cell and molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. DNA Methylation-Mediated Downregulation ofInternational journal of chronic obstructive pulmonary disease · 2025
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rhiannon B WerderMurdoch Children's Research Institute, Melbourne, Australia.ORCID https://orcid.org/0000-0002-6432-4587
Xiaobo ZhouChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael H ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4907-1657
Andrew A WilsonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA awilson@bu.edu.

Funding

A National iPS Cell Network with Deep Phenotyping for Translational ResearchU01TR001810 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILAD, YOAV, KOTTON, DARRELL N. · 2016 to 2020
$4.4M
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5M
Mechanistic studies of the genetic contribution of desmoplakin to pulmonary fibrosis in alveolar type 2 cellsR01HL166407 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANDREW A WILSON, Anny Xiaobo Zhou · 2023 to 2026
$3.1M
Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPDR01HL153248 · NHLBI · UNIVERSITY OF VIRGINIA · PI CHO, MICHAEL H., MANICHAIKUL, ANI WANG · 2021 to 2024
$2.8M
Thyroid Hormone Signaling in Human HepatocytesR01DK117940 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N, WILSON, ANDREW A · 2019 to 2022
$2.7M
Personalized therapy for AATD-associated liver disease via IPS modelingR01DK101501 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WILSON, ANDREW A · 2015 to 2019
$2.4M
NCATS NIH HHS U01 TR001810NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL153248NHLBI NIH HHS R01 HL166407NIDDK NIH HHS R01 DK101501NIDDK NIH HHS R01 DK117940
6 · The paper itself

Abstract

COPD is a major cause of morbidity and mortality globally. While the significance of environmental exposures in disease pathogenesis is well established, the functional contribution of genetic factors has only in recent years drawn attention. Notably, many genes associated with COPD risk are also linked with lung function. Because reduced lung function precedes COPD onset, this association is consistent with the possibility that derangements leading to COPD could arise during lung development. In this review, we summarise the role of leading genes (

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyLungPhenotypePulmonary Disease, Chronic ObstructiveAnimalsGenetic MarkersHumansPrognosisRisk FactorsGenetic Markers

Identifiers

PMID38811034
PMCPMC11134200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.