Evidence map›Paper›PMID 38810991›Full record

ArticleGeriatrics & gerontology international2024

Improvement in gait velocity variability after cerebrospinal fluid elimination and its relationship to clinical symptoms in patients with idiopathic normal pressure hydrocephalus.

Takahiro Yamamoto, Ryoko Fujito, Yoshihiro Chadani, Tetsuo Kashibayashi, Naoto Kamimura, Atsushi Tsuda, Masanori Akamatsu, Takuya Matsushita, Takuji Yamagami, Tetsuya Ueba and 4 more

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In one paragraph

Article in Geriatrics & gerontology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takahiro YamamotoDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID https://orcid.org/0009-0009-8265-6399
Ryoko FujitoDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID https://orcid.org/0000-0003-0178-4444
Yoshihiro ChadaniDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Tetsuo KashibayashiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Naoto KamimuraDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Atsushi TsudaDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Masanori AkamatsuDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Takuya MatsushitaDepartment of Neurology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Takuji YamagamiDepartment of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Tetsuya UebaDepartment of Neurosurgery, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Motoaki SaitoDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Keiji InoueDepartment of Urology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Masashi IzumiDepartment of Rehabilitation Center, Kochi Medical School Hospital, Nankoku, Kochi, Japan.
Hiroaki KazuiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.

Funding

Health and Labour Sciences Research Grant from the Minister of Health, Labour, and Welfare JPMH22GB1002
6 · The paper itself

Abstract

aimThis study aimed to investigate the improvement in gait velocity variability after cerebrospinal fluid (CSF) elimination, and the association between gait velocity variability and gait and cognitive impairment in patients with idiopathic normal pressure hydrocephalus.

methodsThe gait velocity of 44 patients with idiopathic normal pressure hydrocephalus was measured using the Timed Up and Go Test (TUG) for a total of 10 times over 3 days each before and after CSF elimination. The coefficient of variation (CV) in the time required for the sequence of actions in TUG (TUG-CV) was calculated using 10 TUG data, and used for measuring intraindividual gait velocity variability. Gait quality was evaluated with the Gait Status Scale Revised (GSSR), and cognitive function was evaluated with the Mini-Mental State Examination and the Frontal Assessment Battery.

resultsThe TUG, TUG-CV, GSSR and Frontal Assessment Battery results improved significantly after CSF elimination. The analyses using pre-CSF elimination results showed that the TUG-CV significantly and positively correlated with the TUG and GSSR results, and negatively with Mini-Mental State Examination results, but not with age and the Frontal Assessment Battery results. The stepwise multiple regression analysis indicates that the TUG, GSSR and Mini-Mental State Examination results were significant predictors of the TUG-CV. The analysis using data of change after CSF elimination showed that ΔTUG and ΔGSSR were significant predictors of ΔTUG-CV.

conclusionsGait velocity variability improved after CSF elimination, and gait velocity variability was associated with gait disturbances and cognitive impairment in patients with idiopathic normal pressure hydrocephalus. Geriatr Gerontol Int 2024; 24: 693-699.

Indexed as

Hydrocephalus, Normal PressureAgedAged, 80 and overCerebrospinal FluidCognitive DysfunctionFemaleGaitGait Disorders, NeurologicHumansMaleWalking Speedcerebrospinal fluid tap testcognitive impairmentgait velocity variabilityidiopathic normal pressure hydrocephalusTimed Up and Go Test

Identifiers

PMID38810991
PMCPMC11503745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.