Evidence map›Paper›PMID 38810926›Full record

ArticleNeuropharmacology2024

Cholinergic mu-opioid receptor deletion alters reward preference and aversion-resistance.

Cambria R Beane, Delainey G Lewis, Nicolaus Bruns Vi, Kat L Pikus, Mary H Durfee, Roman A Zegarelli, Thomas W Perry, Oscar Sandoval, Anna K Radke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Cambria R BeaneDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Delainey G LewisDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Nicolaus Bruns ViDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Kat L PikusDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Mary H DurfeeDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Roman A ZegarelliDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Thomas W PerryDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Oscar SandovalDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Anna K RadkeDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address: aradke@miamioh.edu.

Funding

Analysis of subcortical networks that promote aversion-resistant alcohol drinkingR15AA027915 · NIAAA · MIAMI UNIVERSITY OXFORD · PI RADKE, ANNA KAY · 2020 to 2020
$378k
Sex-specific effects of infant trauma on adult alcohol drinking: Role of amygdala intercalated neuronsR21AA028602 · NIAAA · MIAMI UNIVERSITY OXFORD · PI QUINN, JENNIFER J · 2021 to 2022
$368k
NIAAA NIH HHS R15 AA027915NIAAA NIH HHS R21 AA028602
6 · The paper itself

Abstract

The endogenous opioid system has been implicated in alcohol consumption and preference in both humans and animals. The mu opioid receptor (MOR) is expressed on multiple cells in the striatum, however little is known about the contributions of specific MOR populations to alcohol drinking behaviors. The current study used mice with a genetic deletion of MOR in cholinergic cells (ChAT-Cre/Oprm1

Indexed as

Alcohol DrinkingMice, KnockoutQuinineReceptors, Opioid, muRewardAnimalsAvoidance LearningCholinergic NeuronsEthanolFemaleInterneuronsMaleMiceNicotineSelf AdministrationSucroseEthanolNicotineOprm protein, mouseQuinineReceptors, Opioid, muSucroseAlcoholAversion-resistanceBinge drinkingCholinergic neuronsMu opioid receptorNicotine

Identifiers

PMID38810926
PMCPMC13285085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.