Evidence map›Paper›PMID 38810774›Full record

ArticleJournal of molecular biology2024

Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX.

Pirada Serena Higbee, Guy W Dayhoff, Asokan Anbanandam, Sameer Varma, Gary Daughdrill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pirada Serena HigbeeThe Department of Molecular Biosciences, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Guy W DayhoffThe Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Asokan AnbanandamThe Department of Molecular Biosciences, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Sameer VarmaThe Department of Molecular Biosciences, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA; The Department of Physics, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
Gary DaughdrillThe Department of Molecular Biosciences, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. Electronic address: gdaughdrill@usf.edu.

Funding

Mechanisms of p53 activation during stress response (MPI)R01CA141244 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JIANDONG CHEN, Gary W Daughdrill · 2009 to 2026
$5.3M
Regulation of transcriptional activation by protein disorderR01GM115556 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CHEN, JIANDONG, DAUGHDRILL, GARY W · 2016 to 2023
$2.6M
NCI NIH HHS R01 CA141244NIGMS NIH HHS R01 GM115556
6 · The paper itself

Abstract

The thermodynamics of secondary p53 binding sites on MDM2 and MDMX were evaluated using p53 peptides containing residues 16-29, 17-35, and 1-73. All the peptides had large, negative heat capacity (ΔC

Indexed as

Cell Cycle ProteinsMolecular Dynamics SimulationProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2ThermodynamicsTumor Suppressor Protein p53Binding SitesHumansProtein BindingProtein ConformationCell Cycle ProteinsMDM2 protein, humanMDM4 protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2TP53 protein, humanTumor Suppressor Protein p53conformational entropycoupled folding and bindingheat capacitymolecular dynamics simulationnuclear magnetic resonance spectroscopy

Identifiers

PMID38810774
PMCPMC12624572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.