Evidence map›Paper›PMID 38810637›Full record

ArticleCurrent biology : CB2024

CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene.

Joshua D Meisel, Presli P Wiesenthal, Vamsi K Mootha, Gary Ruvkun

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. RNA: De-silencing to the rescue.Current biology : CB · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua D MeiselDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
Presli P WiesenthalDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
Vamsi K MoothaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: vamsi@hms.harvard.edu.
Gary RuvkunDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: ruvkun@molbio.mgh.harvard.edu.

Funding

CONTROL OF THE C ELEGANS LINEAGE BY HETEROCHRONIC GENESR01GM044619 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI GARY B RUVKUN · 1991 to 2026
$14.5M
GENETIC AND MOLECULAR BASIS OF LONGEVITYR01AG016636 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GARY B RUVKUN · 1999 to 2026
$12.4M
Preventing and Reversing Mitochondrial Leigh Syndrome with HypoxiaR01NS124679 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Vamsi Krishna Mootha · 2022 to 2026
$2.6M
Identification of genetic and environmental suppressors of mitochondrial dysfunctionK99GM140217 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MEISEL, JOSHUA DANIEL · 2021 to 2022
$200k
Howard Hughes Medical InstituteNIA NIH HHS R01 AG016636NIGMS NIH HHS K99 GM140217NIGMS NIH HHS R01 GM044619NINDS NIH HHS R01 NS124679
6 · The paper itself

Abstract

The mitochondrial proteome is comprised of approximately 1,100 proteins,

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDopaminergic NeuronsElectron Transport Complex IMethyltransferasesMutationAnimalsMitochondriaMitochondrial ProteinsNADH DehydrogenaseCaenorhabditis elegans ProteinsElectron Transport Complex IMethyltransferasesMitochondrial ProteinsNADH DehydrogenaseC. elegansCMTR1complex IG-patch domainhyperoxiaMitochondriamRNA methylationNADH:ubiquinone oxidoreductaseprocessing bodiesSRRT

Identifiers

PMID38810637
PMCPMC11265314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.