Observational studyThe journal of nutrition, health & aging2024
Association between GLIM-diagnosed malnutrition and quality of life in older patients with cancer.
Observational study in The journal of nutrition, health & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global state of GLIM criteria in oncology: a bibliometric analysis of research trends (2019-2025).Frontiers in nutrition · 2026Pooled it
- Global leadership initiative on malnutrition criteria using different muscle mass assessment methods in hemodialysis patients: Links to physical performance, quality of life, and clinical outcomes.European journal of clinical nutrition · 2026Article
- Neutrophil-to-Lymphocyte Ratio and MUST-Defined Nutritional Risk as Independent Correlates of Domain-Specific Quality of Life in Cancer Patients Receiving Chemotherapy.Journal of clinical medicine · 2026Article
- Health-Related Quality of Life Changes in Patients with Digestive Cancers and Chronic Digestive Diseases: A Prospective, Multicenter Study.Journal of clinical medicine · 2026Article
- Article
- Malnutrition predicts severe complications but not survival in laryngeal cancer surgery: a propensity-matched analysis.Frontiers in nutrition · 2026Article
- Health beliefs and quality of life in patients with gastric cancer: the chain mediating role of nutritional behaviors and nutritional status.Frontiers in oncology · 2026Article
- Health insurance coverage for medical nutrition therapy in older women with cancer: a comparative health policy perspective on long-term care, frailty, and survivorship equity.Frontiers in public health · 2026Review
- Trends and disparities in neoplasm-related mortality with death-certificate-documented protein-energy malnutrition in the United States, 1999-2024: a CDC WONDER multiple cause of death study.Frontiers in nutrition · 2026Article
- Oncology nutrition care in Indonesia: a cross-sectional survey to characterise practices, barriers and enablers among nutritionists and dietitians.Frontiers in nutrition · 2026Article
- Cachexia index as a biomarker for cancer cachexia and quality of life in patients with gastric cancer.BMC cancer · 2025Article
- Nutrition impact symptoms as prognostic indicators in gastric cancer: the role of quality of life and survival outcomes.BMC cancer · 2025Article
- Identification of postoperative weight loss trajectories and development of a machine learning-based tool for predicting malnutrition in gastric cancer patients.Frontiers in nutrition · 2025Article
- Value analysis of preoperative NRS2002 and GLIM screening in predicting postoperative complications in patients with gastrointestinal malignancies.Frontiers in nutrition · 2025Article
- Clinical validation of AWGC-defined cachexia in gastric cancer patients: impact on body composition and quality of life.Frontiers in nutrition · 2025Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder patients with cancer have a higher risk for malnutrition and impaired quality of life (QoL). The present study aimed to investigate the relationship between malnutrition diagnosed according to the Global Leadership Initiative Malnutrition (GLIM) criteria and QoL across various tumor types, and to evaluate the combined prognostic value of malnutrition and QoL in predicting survival among older patients with cancer.
methodsThis multicenter, observational cohort study included 5310 older patients with cancer and 2184 with malnutrition (moderate stage, n = 1023; severe stage, n = 1161). An empirical cumulative distribution curve was performed to illustrate the correlation between malnutrition and QoL. The primary objective was to investigate the association between malnutrition and QoL using logistic regression analysis. Survival analyses were performed to assess the combined prognostic value of malnutrition and QoL.
resultsThe median age of the patients (66.9% male, 33.1% female) was 70 years (interquartile range [IQR] 67-74 years) years. The median QoL score was highest in patients without malnutrition (91.88 [IQR 84.44-97.44]), followed by those with moderate (86.15 [IQR 76.18-93.85) and severe (82.31 [IQR 69.87-91.11]) malnutrition. Logistics regression revealed that the risk for developing impaired QoL increased 1.98 (95% confidence interval [CI] 1.64-2.38; P < 0.001) and 2.33 (95% CI 1.93-2.81; P < 0.001) times in patients with moderate and severe malnutrition, respectively. Kaplan-Meier curves showed that QoL in combination with GLIM criteria demonstrated a significant discriminative performance for survival and served as an independent prognostic factor among older patients with cancer, especially for lung and gastric cancers.
conclusionsMalnutrition diagnosed according to the GLIM criteria was a predictor of impaired QoL. Additionally, the combination of QoL and malnutrition demonstrated utility for predicting survival outcomes in older patients with cancer.
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