ArticleScience advances2024
Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.
Registry-linked trialAbstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
2 citing papers in PubMed.
- Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.PLoS genetics · 2025Article
- Molecular Thumbprints: Biological Signatures That Measure Loss of Identity.Biomolecules · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
82 authors.
David A DrewClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8813-0816
Andre E KimDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-8644-614X
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
John MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1478-9965
Juan Pablo LewingerDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0692-2570
Eric KawaguchiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jun WangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8372-1863
Yubo FuDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Natalia ZemlianskaiaDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9976-0784
Virginia Díez-ObreroColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-8713-4583
Niki DimouNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-1678-9328
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
James W BaurleyBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria 3010 Australia.ORCID 0000-0003-2225-6675
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-5439-1500
Ross L PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0003-2849-5757
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0001-8540-6891
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Emmanouil BourasLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0003-1489-5506
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Arif BudiartoBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Peter T CampbellDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Robert Carreras-TorresColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2925-734X
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-1584-5551
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David V ContiDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Matthew A M DevallDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-5943-4397
Jane C FigueiredoDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Stephen B GruberDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0001-8656-7822
Andrea GsurCenter for Cancer Research, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-9795-1528
Marc J GunterNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0001-5472-6761
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-4173-7530
Akihisa HidakaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-6027-9806
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-8964-6160
Kristina M JordahlPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-5165-5769
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3084-2287
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-1802-9517
Brigid M LynchCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-8060-547X
Neil MurphyNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.ORCID 0000-0001-9914-7851
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Christina C NewtonDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.ORCID 0000-0003-1471-5608
Mireia Obón-SantacanaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Shuji OginoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0002-3909-2323
Jennifer OseHuntsman Cancer Institute, Salt Lake City, UT, USA.ORCID 0000-0002-2030-9676
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.ORCID 0000-0002-2692-221X
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.ORCID 0000-0002-6534-335X
Nikos PapadimitriouNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Bens PardameanBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.ORCID 0000-0002-7404-9005
Andrew J PellattDepartment of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0127-9790
Anita R PeoplesHuntsman Cancer Institute, Salt Lake City, UT, USA.ORCID 0000-0003-3645-3960
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-3676-8954
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID 0000-0002-8512-068X
Edward Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-0339-5824
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-0900-5735
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Stephanie L SchmitGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-5931-1194
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0001-7153-2766
Mariana C SternDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Yu-Ru SuBiostatistics Division, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0001-6150-960X
Duncan C ThomasDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yu TianDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7218-5954
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK.ORCID 0000-0002-8452-8472
Cornelia M UlrichHuntsman Cancer Institute, Salt Lake City, UT, USA.ORCID 0000-0001-7641-059X
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.ORCID 0000-0001-5449-6230
Fränzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands.ORCID 0000-0001-8367-2352
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.ORCID 0000-0002-9692-101X
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-8168-4712
Victor MorenoColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2818-5487
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-5666-9318
Andrew T ChanClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7284-6767
W James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6626-9091
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MVECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0MColorectal Chemoprevention with Calcium and Vitamin DR01CA098286 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARON, JOHN ANTHONY · 2003 to 2015
$43.9MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5MIntramural NIH HHS Z01 CP010200NCATS NIH HHS KL2 TR000421NCI NIH HHS K05 CA152715NCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA059005NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA066635NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA097325NCI NIH HHS R01 CA098286NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA155101NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA207371NCI NIH HHS R01 CA242218NCI NIH HHS R01 CA244588NCI NIH HHS R01 CA254108NCI NIH HHS R01 CA263318NCI NIH HHS R01 CA273198NCI NIH HHS R03 CA153323NCI NIH HHS R03 CA270473NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA206110NCI NIH HHS U01 CA261339NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS UM1 CA182883NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201700006CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS K01 DK120742NIDDK NIH HHS P30 DK034987NIH HHS S10 OD028685WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
Abstract
Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit
Indexed as
Anti-Inflammatory Agents, Non-SteroidalColorectal NeoplasmsGenome-Wide Association StudyPolymorphism, Single NucleotideAgedAspirinCase-Control StudiesFemaleGenetic LociGenetic Predisposition to DiseaseHumansMaleMiddle AgedReceptors, Prostaglandin E, EP4 SubtypeAnti-Inflammatory Agents, Non-SteroidalAspirinPTGER4 protein, humanReceptors, Prostaglandin E, EP4 Subtype
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.