Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Bouchra AttiaLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7255, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0009-0009-5537-699X
Laetitia MyLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Turing Center for Living Systems, CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0002-7876-1809
Jean Philippe CastaingLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Turing Center for Living Systems, CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.
Céline DinetLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Turing Center for Living Systems, CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0002-8987-936X
Hugo Le GuennoInstitut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0003-1768-1212
Victoria SchmidtLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7255, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0001-8477-8765
Leon EspinosaLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Turing Center for Living Systems, CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0002-1923-2069
Vivek AnantharamanNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0001-8395-0009
L AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-0771-253X
Corinne Sebban-KreuzerLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7255, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0001-8955-5763
Matthieu NouaillerLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7255, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0003-2061-466X
Olivier BornetInstitut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0001-8931-4353
Patrick ViollierDepartment of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire, University of Geneva, 1211 Genève 4, Switzerland.ORCID 0000-0002-5249-9910
Latifa ElantakLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Institut de Microbiologie de la Méditerranée (IMM), CNRS - Aix-Marseille Université UMR7255, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0002-4090-9441
Tâm MignotLaboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Turing Center for Living Systems, CNRS - Aix-Marseille Université UMR7283, 31 Chemin Joseph Aiguier CS70071, 13402 Marseille Cedex 20, France.ORCID 0000-0003-4338-9063
Funding
Evolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3M
6 · The paper itself
Abstract
Cell motility universally relies on spatial regulation of focal adhesion complexes (FAs) connecting the substrate to cellular motors. In bacterial FAs, the Adventurous gliding motility machinery (Agl-Glt) assembles at the leading cell pole following a Mutual gliding-motility protein (MglA)-guanosine 5'-triphosphate (GTP) gradient along the cell axis. Here, we show that GltJ, a machinery membrane protein, contains cytosolic motifs binding MglA-GTP and AglZ and recruiting the MreB cytoskeleton to initiate movement toward the lagging cell pole. In addition, MglA-GTP binding triggers a conformational shift in an adjacent GltJ zinc-finger domain, facilitating MglB recruitment near the lagging pole. This prompts GTP hydrolysis by MglA, leading to complex disassembly. The GltJ switch thus serves as a sensor for the MglA-GTP gradient, controlling FA activity spatially.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A molecular switch controls assembly of bacterial focal adhesions. · full record | OpenQuestion