Evidence map›Paper›PMID 38809964›Full record

ArticleScience translational medicine2024

Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1.

José Victor Zambrana, Chloe M Hasund, Rosemary A Aogo, Sandra Bos, Sonia Arguello, Karla Gonzalez, Damaris Collado, Tatiana Miranda, Guillermina Kuan, Aubree Gordon and 3 more

Abstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges.Current topics in microbiology and immunology · 2026
    Review
  11. Zika immune imprint risks dengue.Nature immunology · 2026
    Article
  12. Article
  13. First record of Zika virus in Yemen.Current research in parasitology & vector-borne diseases · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. CD4Vaccines · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

José Victor ZambranaSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0000-0003-0107-6173
Chloe M HasundViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0009-0009-3513-562X
Rosemary A AogoViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0003-4588-4914
Sandra BosDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0001-5036-0336
Sonia ArguelloSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0009-0005-0915-5273
Karla GonzalezSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0009-0001-4881-5802
Damaris ColladoSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0000-0002-0878-3260
Tatiana MirandaSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0000-0001-7358-982X
Guillermina KuanSustainable Sciences Institute, Managua 14006, Nicaragua.ORCID 0000-0002-5251-173X
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9352-7877
Angel BalmasedaSustainable Sciences Institute, Managua 14006, Nicaragua.
Leah C KatzelnickViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0003-1033-6758
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.ORCID 0000-0002-7238-4037

Funding

Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WOLINSKY, STEVEN M · 2015 to 2021
$46.6M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aravinda M. DeSilva · 2015 to 2026
$34.1M
Immunology, virology, and epidemiology of flaviviruses and other emerging virusesZIAAI001346 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KATZELNICK, LEAH · 2021 to 2025
$7.1M
Living in the post-Zika world: Impact of interactions between dengue and Zika viruses on diagnostics, antibody dynamics, and correlates of disease riskU01AI153416 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS, EVA · 2021 to 2025
$4.9M
Epidemiological, Clinical & Immunological Studies of Zika, dengue and chikungunyaR01AI099631 · NIAID · SUSTAINABLE SCIENCES INSTITUTE · PI BALMASEDA, ANGEL LAZARO · 2012 to 2021
$1.8M
NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI099631NIAID NIH HHS U01 AI153416NIAID NIH HHS U19 AI118610
6 · The paper itself

Abstract

Infection with any of the four dengue virus serotypes (DENV1-4) can protect against or enhance subsequent dengue depending on preexisting antibodies and infecting serotype. Additionally, primary infection with the related flavivirus Zika virus (ZIKV) is associated with increased risk of DENV2 disease. Here, we measured how prior DENV and ZIKV immunity influenced risk of disease caused by DENV1-4 in a pediatric Nicaraguan cohort. Of 3412 participants in 2022, 10.6% experienced dengue cases caused by DENV1 (

Indexed as

DengueDengue VirusSerogroupZika VirusZika Virus InfectionAdolescentAntibodies, ViralChildChild, PreschoolCohort StudiesFemaleHumansMaleNicaraguaRisk FactorsAntibodies, Viral

Identifiers

PMID38809964
PMCPMC11927040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.