Evidence map›Paper›PMID 38809931›Full record

ArticlePloS one2024

Discussion on the relationship between gut microbiota and glioma through Mendelian randomization test based on the brain gut axis.

Chenzhi Cui, Tianke Yang, ShengYu Wang, Zhuqiang Jia, Lin Zhao, Xin Han, Xiaohong Sun, Junwei Zong, Shouyu Wang, Dong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenzhi CuiGraduate school, Dalian Medical University, Dalian, Dalian, China.
Tianke YangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
ShengYu WangMedical Laboratory Technology, College of Medical Laboratory, Dalian Medical University, Dalian, China.
Zhuqiang JiaThe First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lin ZhaoDepartment of Quality Management, Dalian Municipal Central Hospital, Dalian, China.
Xin HanNaqu People's Hospital, Tibet, China.
Xiaohong SunDepartment of Nursing, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Junwei ZongDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Shouyu WangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0000-0002-2808-0247
Dong ChenGraduate school, Dalian Medical University, Dalian, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the realm of Gut-Brain axis research, existing evidence points to a complex bidirectional regulatory mechanism between gut microbiota and the brain. However, the question of whether a causal relationship exists between gut microbiota and specific types of brain tumors, such as gliomas, remains unresolved. To address this gap, we employed publicly available Genome-Wide Association Study (GWAS) and MIOBEN databases, conducting an in-depth analysis using Two-Sample Mendelian Randomization (MR).

methodWe carried out two sets of MR analyses. The preliminary analysis included fewer instrumental variables due to a high genome-wide statistical significance threshold (5×10-8). To enable a more comprehensive and detailed analysis, we adjusted the significance threshold to 1×10-5. We performed linkage disequilibrium analysis (R2 <0.001, clumping distance = 10,000kb) and detailed screening of palindromic SNPs, followed by MR analysis and validation through sensitivity analysis.

resultsOur findings reveal a causal relationship between gut microbiota and gliomas. Further confirmation via Inverse Variance Weighting (IVW) identified eight specific microbial communities related to gliomas. Notably, the Peptostreptococcaceae and Olsenella communities appear to have a protective effect, reducing glioma risk.

conclusionThis study not only confirms the causal link between gut microbiota and gliomas but also suggests a new avenue for future glioma treatment.

Indexed as

Brain NeoplasmsGastrointestinal MicrobiomeGenome-Wide Association StudyGliomaMendelian Randomization AnalysisPolymorphism, Single NucleotideBrain-Gut AxisHumansLinkage Disequilibrium

Identifiers

PMID38809931
PMCPMC11135782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.