Evidence map›Paper›PMID 38809876›Full record

ArticlePloS one2024

Detection and genetic diversity of parechoviruses in children with acute flaccid paralysis in Cameroon.

Daniel Kamga Njile, Emmanuel Akongnwi Mugyia, Marie Claire Endegue-Zanga, Jude Anfumbom Kfutwah, Marlise Dontsop Djoumetio, Boyomo Onana, Ousmane Madiagne Diop, Richard Njouom, Serge Alain Sadeuh-Mba

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In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel Kamga NjileDepartment of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.ORCID 0009-0008-9134-7320
Emmanuel Akongnwi MugyiaFaculty of Science, Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
Marie Claire Endegue-ZangaDepartment of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
Jude Anfumbom KfutwahWorld Health Organization, Regional Office, Libreville, Gabon.ORCID 0000-0002-1287-5934
Marlise Dontsop DjoumetioWorld Health Organization, Country Office, Yaoundé, Cameroon.
Boyomo OnanaFaculty of Sciences, Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon.
Ousmane Madiagne DiopGlobal Polio Eradication Initiative (GPEI), World Health Organization, Geneva, Switzerland.
Richard NjouomDepartment of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
Serge Alain Sadeuh-MbaDepartment of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Human Parechoviruses (HPeVs) have rarely been considered in the virological investigation of Acute Flacid Paralysis (AFP) cases in Africa, where enteric infections are very common. This study investigated the prevalence and genetic diversity of HPeV in 200 children aged ≤ 15 years with AFP in Cameroon from 2018 to 2019. HPeVs were detected in their faecal RNA using 5'-untranslated real-time RT-PCR. Detected HPeVs were typed by phylogenetic comparison with homologous sequences from homotypic reference strains. Overall, HPeV RNA was detected in 11.0% (22/200) of the 200 stool samples tested. Twelve HPeVs were successfully sequenced and reliably assigned to HPeV-A1, A4, A5, A10, A14, A15, A17 and A18 genotypes. Phylogenetic analyses revealed a high genetic variability among the studied HPeVs, as well as between the studied HPeVs and their previously reported counterparts from Cameroon in 2014. These findings suggest that different HPeV genotypes co-circulate in Cameroon without documented epidemics.

Indexed as

FecesGenetic VariationGenotypeParechovirusPhylogenyPicornaviridae InfectionsAdolescentCameroonChildChild, PreschoolFemaleHumansInfantMaleParalysisRNA, ViralRNA, Viral

Identifiers

PMID38809876
PMCPMC11135751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.