Evidence map›Paper›PMID 38809712›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low-voltage-fast onset seizures in Dravet syndrome.

Fabrizio Capitano, Mathieu Kuchenbuch, Jennifer Lavigne, Hava Chaptoukaev, Maria A Zuluaga, Marco Lorenzi, Rima Nabbout, Massimo Mantegazza

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fabrizio CapitanoUniversity Cote d'Azur, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis 06560, France.ORCID 0000-0002-5718-4002
Mathieu KuchenbuchReference Centre for Rare Epilepsies, Member of European Reference Network EpiCARE, Department of Pediatric Neurology, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris 75015, France.ORCID 0000-0002-5944-2204
Jennifer LavigneUniversity Cote d'Azur, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis 06560, France.
Hava ChaptoukaevEURECOM, Biot-Sophia Antipolis 06410, France.ORCID 0009-0000-0859-4059
Maria A ZuluagaEURECOM, Biot-Sophia Antipolis 06410, France.ORCID 0000-0002-1147-766X
Marco LorenziUniversity Cote d'Azur, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis 06560, France.ORCID 0000-0003-0521-2881
Rima NabboutReference Centre for Rare Epilepsies, Member of European Reference Network EpiCARE, Department of Pediatric Neurology, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris 75015, France.
Massimo MantegazzaUniversity Cote d'Azur, Institute of Molecular and Cellular Pharmacology, Valbonne-Sophia Antipolis 06560, France.ORCID 0000-0002-1070-7929

Funding

Agence Nationale de la Recherche (ANR) ANR-11-LABX-0015-01Agence Nationale de la Recherche (ANR) ANR-15-IDEX-01Ville de Nice, France Aides Individuelles Jeunes Chercheurs
6 · The paper itself

Abstract

Epilepsies have numerous specific mechanisms. The understanding of neural dynamics leading to seizures is important for disclosing pathological mechanisms and developing therapeutic approaches. We investigated electrographic activities and neural dynamics leading to convulsive seizures in patients and mouse models of Dravet syndrome (DS), a developmental and epileptic encephalopathy in which hypoexcitability of GABAergic neurons is considered to be the main dysfunction. We analyzed EEGs from DS patients carrying a

Indexed as

Epilepsies, MyoclonicGABAergic NeuronsHippocampusInterneuronsNAV1.1 Voltage-Gated Sodium ChannelSeizuresAnimalsChildDisease Models, AnimalElectroencephalographyFemaleHumansMaleMiceNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, humanScn1a protein, mouseepilepsyexcitabilityGABAseizure predictionsodium channels

Identifiers

PMID38809712
PMCPMC11161744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.