Evidence map›Paper›PMID 38809623›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Assessment of the Dosimetric Index from IMRT and Rapid arc Plan for Oropharyngeal Cancer with Simultaneous Integrated Boost (SIB) Technique in Combination with EUD-based NTCP and TCP Radiobiological Models.

Sougoumarane Dashnamoorthy, Ebenezar Jeyasingh, Karthick Rajamanickam, Imtiaz Ahmed

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Sougoumarane DashnamoorthyThangam Hospital, Namakkal, India.
Ebenezar JeyasinghJamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, India.
Karthick RajamanickamThangam Hospital, Namakkal, India.
Imtiaz AhmedDepartment of Radiation Oncology KLES Dr Prabhakar Kore Hospital and MRC, Belgaum, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current research compared radiobiological and dosimetric results for simultaneous integrated boost (SIB) plans employing RapidArc and IMRT planning procedures in oropharyngeal cancer from head-and-neck cancer (HNC) patients. MATERIALS AND

methodsThe indigenously developed Python-based software was used in this study for generation and analysis. Twelve patients with forty-eight total plans with SIB were planned using Rapid arc (2 and 3 arcs) and IMRT (7 and 9 fields) and compared with radiobiological models Lyman, Kutcher, Burman (LKB) and EUD (Equivalent Uniform Dose) along with physical index such as homogeneity index(HI), conformity index(CI) of target volumes.

resultsThese models' inputs are the dose-volume histograms (DVHs) calculated by the treatment planning system (TPS). The values obtained vary from one model to the other for the same technique and patient. The maximum dose to the brainstem and spinal cord and the mean dose to the parotids were analysed both dosimetrically and radiobiologically, such as the LKB model effective volume, equivalent uniform dose, EUD-based normal tissue complication probability, and normal tissue integral dose. The mean and max dose to target volume with conformity, homogeneity index, tumor control probability compared with treatment times, and monitor units.

conclusionRapid arc (3 arcs) resulted in significantly better OAR sparing, dose homogeneity, and conformity. The findings indicate that the rapid arc plan has improved dose distribution in the target volume compared with IMRT, but the tumor control probability obtained for the two planning methods, Rapid arc (3 arcs) and IMRT (7 fields), are similar. The treatment time and monitor units for the Rapid arc (3 arcs) were superior to other planning methods and considered to be standard in head & neck radiotherapy.

Indexed as

Organs at RiskOropharyngeal NeoplasmsRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedHumansPrognosisRadiobiologyRadiometryIMRTNTCPPythonRapid arcTCP

Identifiers

PMID38809623
PMCPMC11318801

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