Evidence map›Paper›PMID 38809324›Full record

ArticleEuropean journal of nutrition2024

Dietary intake of branched-chain amino acids (BCAAs), serum BCAAs, and cardiometabolic risk markers among community-dwelling adults.

Songxian Rao, Yaozong Zhang, Shaoyu Xie, Hongjuan Cao, Zhuang Zhang, Wanshui Yang

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Songxian Rao *Department of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
Yaozong Zhang *Department of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
Shaoyu XieDepartment of Chronic Non-communicable Diseases Prevention and Control, Lu'an Municipal Center for Disease Control and Prevention, Lu'an, Anhui, People's Republic of China.
Hongjuan CaoDepartment of Chronic Non-communicable Diseases Prevention and Control, Lu'an Municipal Center for Disease Control and Prevention, Lu'an, Anhui, People's Republic of China.
Zhuang ZhangDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
Wanshui YangDepartment of Nutrition, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. wanshuiyang@gmail.com.ORCID http://orcid.org/0000-0002-7365-2689

Funding

grants from Anhui Medical University 2021xkjT007, 2020lcxk033, XJ201935, and 2019xkj161National Natural Science Foundation of China 82073651Science Fund for Distinguished Young Scholars of Anhui Province 2008085MH262Science Fund for Distinguished Young Scholars of Anhui Province 2108085QH357Scientific Research Foundation of Education Department of Anhui Province of China gxyqZD2021099
6 · The paper itself

Abstract

purposeTo investigate the associations between dietary/serum branched-chain amino acids (BCAAs) and cardiometabolic risk markers.

methodsIn a cohort of 2791 participants, diet and cardiometabolic risk markers were measured twice at baseline in overall participants and after 1-year in a subset of 423 participants. We assessed serum BCAAs at baseline and arterial stiffness after 1-year. The cross-sectional associations between dietary/serum BCAAs and cardiometabolic risk markers were analyzed using baseline measurements by linear regression, while the 1-year longitudinal association were analyzed using repeated measurements by linear mixed-effects regression.

resultsHigher BCAA intake from poultry was associated with lower triglycerides (β=-0.028, P = 0.027) and higher high-density lipoprotein cholesterol (HDL-C, β = 0.013, P = 0.006), while BCAAs in red and processed meat or fish were inversely associated with low-density lipoprotein cholesterol (β = 0.025, P = 0.001) and total cholesterol (β = 0.012, P = 0.033), respectively. BCAAs in whole grains and nuts were associated with higher HDL-C (β = 0.011, P = 0.016), and lower TG (β=-0.021, P = 0.041) and diastolic blood pressure (β=-0.003, P = 0.027). Also, BCAAs from soy or vegetables and fruits were inversely associated with arterial stiffness (β=-0.018, P = 0.047) and systolic blood pressure (β=-0.011, P = 0.003), respectively. However, BCAAs in refined grains were positively associated with triglycerides (β = 0.037, P = 0.014). Total serum BCAAs were unfavorably associated with multiple cardiometabolic risk markers (all P < 0.05).

conclusionDietary BCAAs in poultry, whole grains and nuts, soy, and vegetables and fruits may be favorably, while BCAAs in red and processed meat, fish, and refined grains were unfavorably associated with cardiometabolic health. Serum BCAAs showed a detrimental association with cardiometabolic risk markers.

Indexed as

Amino Acids, Branched-ChainBiomarkersCardiometabolic Risk FactorsDietAdultAgedAnimalsCardiovascular DiseasesCholesterol, HDLCohort StudiesCross-Sectional StudiesFemaleHumansIndependent LivingLongitudinal StudiesMaleAmino Acids, Branched-ChainBiomarkersCholesterol, HDLTriglyceridesBranched-chain amino acidsCardiometabolic risk markerDiet

Identifiers

PMID38809324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.