Evidence map›Paper›PMID 38809271›Full record

SynthesisJournal of neurology2024

Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review.

Francescopaolo Cucinotta, Bart Swinnen, Elena Makovac, Stephanie Hirschbichler, Erlick Pereira, Simon Little, Francesca Morgante, Lucia Ricciardi

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. How to treat cardiovascular autonomic failure in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francescopaolo Cucinotta *Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Bart Swinnen *UCSF, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Elena MakovacNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK.
Stephanie HirschbichlerKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500, Krems, Austria.
Erlick PereiraNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK.
Simon LittleUCSF, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Francesca MorganteNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK.
Lucia RicciardiNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, UK. lricciar@sgul.ac.uk.ORCID http://orcid.org/0000-0001-9401-3301

Funding

Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
NINDS NIH HHS K23 NS120037
6 · The paper itself

Abstract

backgroundAutonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients.

methodsWe conducted a systematic literature search in PubMed/MEDLINE.

results36 out of 472 studies were included, mostly involving DBS of the subthalamic nucleus, and to a lesser extent the globus pallidus pars interna and pedunculopontine nucleus. Seventeen studies evaluated the effect of DBS on patient-reported or clinician-rated cardiovascular symptoms, showing an improvement in the first year after surgery but not with longer-term follow-up. DBS has no clear direct effects on blood pressure during an orthostatic challenge (n = 10 studies). DBS has inconsistent effects on heart rate variability (n = 10 studies).

conclusionCurrent evidence on the impact of DBS on cardiovascular functions in PD is inconclusive. DBS may offer short-term improvement of cardiovascular symptoms in PD, particularly orthostatic hypotension, which may be attributed to dopaminergic medication reduction after surgery. There is insufficient evidence to draw conclusions on the direct effect of DBS on blood pressure and heart rate variability.

Indexed as

Deep Brain StimulationParkinson DiseaseBlood PressureCardiovascular DiseasesHumansCardiovascular functionsDeep brain stimulationHeart rate variabilityParkinson’s disease

Identifiers

PMID38809271
PMCPMC11233308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.