Evidence map›Paper›PMID 38808967›Full record

ArticleAnnals of clinical and translational neurology2024

Concussion burden and later-life cardiovascular risk factors in former professional American-style football players.

Can Ozan Tan, Rachel Grashow, Roland Thorpe, Karen K Miller, David M Nathan, Saef Izzy, Farid Radmanesh, Jonathan H Kim, Marc G Weisskopf, Herman A Taylor and 2 more

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Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Can Ozan Tan *RAM Group, Department of Electrical Engineering, Mathematics, and Computer Science, University of Twente, the Netherlands.ORCID 0000-0001-9673-9907
Rachel Grashow *Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-6961-0243
Roland ThorpeProgram of Research on Men's Health, Hopkins Center for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Karen K MillerFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
David M NathanFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Saef IzzyDepartment of Neurology, Divisions of Stroke, Cerebrovascular, and Critical Care Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Farid RadmaneshDepartment of Neurology, Divisions of Stroke, Cerebrovascular, and Critical Care Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jonathan H KimEmory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Marc G WeisskopfFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4513-9834
Herman A TaylorFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Ross D ZafonteFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Aaron L BaggishFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Why Place MattersU54MD000214 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI THORPE, ROLAND J. · 2017 to 2022
$8.8M
Stress and Mortality Among Black MenK02AG059140 · NIA · JOHNS HOPKINS UNIVERSITY · PI THORPE, ROLAND J. · 2018 to 2022
$1.1M
Harvard Catalyst/The Harvard Clinical and Translational Science CenterNational Football League Players AssociationNIA NIH HHS K02 AG059140NIH HHS K02AG059140NIH HHS U54MD000214NIMHD NIH HHS U54 MD000214
6 · The paper itself

Abstract

objectiveMid-life cardiovascular risk factors are associated with later cognitive decline. Whether repetitive head injury among professional athletes impacts cardiovascular risk is unknown. We investigated associations between concussion burden and postcareer hypertension, high cholesterol, and diabetes among former professional American-style football (ASF) players.

methodsIn a cross-sectional study of 4080 professional ASF players conducted between January 2015 and March 2022, we used an mulitsymptom concussion symptom score (CSS) and the number of loss-of-consciousness (LOC) episodes as a single severe symptom to quantify football-related concussion exposure. Primary outcomes were hypertension, dyslipidemia, and diabetes, defined by current or recommended prescription medication use.

resultsThe prevalence of hypertension, high cholesterol, and diabetes among former players (52 ± 14 years of age) was 37%, 34%, and 9%. Concussion burden was significantly associated with hypertension (lowest vs. highest CSS quartile, odds ratio (OR) = 1.99; 95%CI: 1.33-2.98; p < 0.01) and high cholesterol (lowest vs. moderate CSS, OR = 1.46, 95%CI, 1.11-1.91; p < 0.01), but not diabetes. In fully adjusted models, the prevalence of multiple CVD was associated with CSS. These results were driven by younger former players (≤ 40 year of age) in which the odds of hypertension were over three times higher in those in the highest CSS quartile (OR = 3.29, 95%CI: 1.39-7.61; p = 0.01). Results were similar for LOC analyses.

interpretationPrior concussion burden is associated with postcareer atherogenic cardiovascular risk profiles among former professional American football players.

Indexed as

Brain ConcussionFootballHeart Disease Risk FactorsHypertensionAdultAgedAthletesAthletic InjuriesCardiovascular DiseasesCross-Sectional StudiesDiabetes MellitusHumansMaleMiddle AgedPrevalenceRisk Factors

Identifiers

PMID38808967
PMCPMC11187967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.