Evidence map›Paper›PMID 38808719›Full record

ArticleAnti-cancer agents in medicinal chemistry2024

Moscatilin Reverses EMT Progression and its Resulting Enhanced Invasion and Migration by Affecting the TGF-β Signaling Pathway in Bladder Cancer.

Zhihao Li, Jin Yang, Lin Chen, Pei Chen, Chenhuan Liu, Xiaoming Long, Bo Chen, Jun Long

Abstract read
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In one paragraph

Article in Anti-cancer agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Bibenzyl fromAntioxidants (Basel, Switzerland) · 2025
    Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhihao LiCollege of Pharmacy, Chengdu University, Chengdu, China.
Jin YangClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Lin ChenClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Pei ChenClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Chenhuan LiuClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Xiaoming LongClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Bo ChenClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.
Jun LongClinical Medical College and Affiliated Hospital, Chengdu University, Chengdu, China.

Funding

Chengdu Science and Technology Bureau 2022-YF05-01441-SNSichuan Province Science and Technology Support Program 2022NSFSC1592Sichuan Provincial Youth Science and Technology Fund Q20013,Q20013,S22002,Q23002
6 · The paper itself

Abstract

backgroundBladder cancer metastasis is an essential process in the progression of muscle-invasive bladder cancer. EMT plays a crucial role in facilitating the spread of cancer cells. Identifying compounds that can inhibit these abilities of cancer cells is a significant international endeavor.

objectiveTo explore the migration and invasion effect of Moscatilin on the bladder and clarify the mechanism of action Methods: The anti-bladder cancer effect of Moscatilin was observed by a cell proliferation experiment. The migration and invasion of bladder cancer cells inhibited by Moscatilin were detected by Transwell and Wound healing. The effects of Moscatilin on EMT-related proteins E-cadherin, N-cadherin, Snail1, Vimentin, and TGF-β signaling pathways were detected by Western blot, and nucleic acid levels were verified by qPCR.

resultsOur study revealed that Moscatilin reduced the viability of bladder cancer cells in vitro and impeded their migration and invasion in experimental settings. Furthermore, we observed that Moscatilin decreased the activation levels of active proteins, specifically Smad3, Samd2, and MMP2. Additionally, we found that moscatilin significantly reduced the expression level of TGF-β and was also capable of reversing the overexpression effect of TGF-β. Treatment with Moscatilin also led to significant inhibition of interstitial cell markers Ncadherin and Snail1, which are associated with EMT.

conclusionThese findings indicate that Moscatilin impedes the migration and invasion of bladder cancer cells by influencing cell survival, modulating TGF-β/Smad signaling, and inhibiting EMT.

Indexed as

Cell MovementCell ProliferationDrug Screening Assays, AntitumorEpithelial-Mesenchymal TransitionSignal TransductionTransforming Growth Factor betaUrinary Bladder NeoplasmsAntineoplastic AgentsCell SurvivalDose-Response Relationship, DrugHumansMolecular StructurePyrazolesQuinolinesStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsLY-2157299PyrazolesQuinolinesTransforming Growth Factor betaBladder cancerEMTMMP2.N-cadherinsnail1TGF-β/smad signaling

Identifiers

PMID38808719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.