Evidence map›Paper›PMID 38808708›Full record

ArticleCurrent pharmaceutical design2024

Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and Vanillin/Nicotinamide.

Manhel R Bahry, Taghreed H Al-Noor, Ali M Fardous, Ahmad R Heydari, Aly Abdou, Shaimaa Fayez, Mohamed El-Shazly, Na'il Saleh

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Article in Current pharmaceutical design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manhel R BahryDepartment of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, U.S.A.
Taghreed H Al-NoorDepartment of Chemistry, Education of Pure Science, College Ibn Al-Haitham, University of Baghdad, Baghdad, Iraq.
Ali M FardousDepartment of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, U.S.A.
Ahmad R HeydariDepartment of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, U.S.A.
Aly AbdouChemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.
Shaimaa FayezDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt.
Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt.
Na'il SalehDepartment of Chemistry, College of Science, United Arab Emirates University, Al Ain, P.O. Box 15551, United Arab Emirates.ORCID 0000-0003-3282-1156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study focuses on the development of novel antimicrobial agents. A Schiff base ligand, 6-(2-(4-hydroxy-3-methoxybenzylideneamino)-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, synthesized through the condensation of amoxicillin and vanillin in methanol, served as the foundation. Polydentate mixed ligand complexes were then formed by reacting the Schiff base with metal ions (Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)) and nicotinamide in specific ratios.

methodsCharacterization involved various techniques, such as

resultsQuantum chemical features of both ligands and metal complexes were computed, refining their electronic and molecular structures theoretically. Antimicrobial activity against

conclusionThis study underscores the potential applications of the Schiff base ligands and their metal complexes in developing new antimicrobial agents.

Indexed as

Anti-Bacterial AgentsBenzaldehydesMicrobial Sensitivity TestsNiacinamideSchiff BasesCoordination ComplexesEscherichia coliLigandsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsBenzaldehydesCoordination ComplexesLigandsNiacinamideSchiff BasesvanillinAmoxicillinantibacterial evaluationmetal ions.molecular dockingnicotinamide-mixed ligand complexesSchiff base

Identifiers

PMID38808708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.