Evidence map›Paper›PMID 38808257›Full record

ArticleFrontiers in pharmacology2024

Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles.

Elsayed A Elmorsy, Sameh Saber, Ahmed Y Kira, Abdullah Alghasham, Mohamed R Abdel-Hamed, Maha M Amer, Enas A Mohamed, A AlSalloom A, Abdullah S Alkhamiss, Rabab S Hamad and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elsayed A ElmorsyDepartment of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Sameh SaberDepartment of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Ahmed Y KiraDepartment of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Abdullah AlghashamDepartment of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Mohamed R Abdel-HamedDepartment of Anatomy, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Maha M AmerDepartment of Anatomy, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Enas A MohamedDepartment of Anatomy, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
A AlSalloom ADepartment of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Abdullah S AlkhamissDepartment of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Rabab S HamadBiological Sciences Department, College of Science, King Faisal University, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Abousree T EllethyDepartment of Oral and Medical Basic Sciences, Biochemistry Division, College of Dentistry, Qassim University, Buraydah, Saudi Arabia.
Hossam A ElsisiDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
Mansour AlsharidahDepartment of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Sahar R ElghandourDepartment of Anatomy and Histology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Tayseer ElnawawyDepartment of Pharmaceutics, Egyptian Drug Authority, Cairo, Egypt.
Rasha AbdelhadyPharmacology and Toxicology Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis is a disease with a great global health and economic burden. Existing data highlights itraconazole (ITRCZ) as a potentially effective anti-fibrotic therapy. However, ITRCZ effect is hindered by several limitations, such as poor solubility and bioavailability. This study aimed to formulate and optimize chitosan nanoparticles (Cht NPs) loaded with ITRCZ as a new strategy for managing liver fibrosis. ITRCZ-Cht NPs were optimized utilizing a developed 2

Indexed as

anti-fibrotichedgehog signalinginflammationitraconazoleliver fibrosisnanotechnolody

Identifiers

PMID38808257
PMCPMC11130383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.