Evidence map›Paper›PMID 38808246›Full record

ArticleRSC advances2024

Preparation of von Hippel-Lindau (VHL) E3 ubiquitin ligase ligands exploiting constitutive hydroxyproline for benzylic amine protection.

Diana M Soto-Martínez, Garrett D Clements, John E Díaz, Joy Becher, Robert C Reynolds, Christina Ochsenbauer, Timothy S Snowden

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diana M Soto-MartínezDepartment of Chemistry and Biochemistry, The University of Alabama 250 Hackberry Lane Tuscaloosa AL 35487 USA snowden@ua.edu.ORCID https://orcid.org/0009-0000-8968-6253
Garrett D ClementsDepartment of Chemistry and Biochemistry, The University of Alabama 250 Hackberry Lane Tuscaloosa AL 35487 USA snowden@ua.edu.ORCID https://orcid.org/0009-0004-9664-1976
John E DíazDepartment of Chemistry and Biochemistry, The University of Alabama 250 Hackberry Lane Tuscaloosa AL 35487 USA snowden@ua.edu.
Joy BecherDepartment of Chemistry and Biochemistry, The University of Alabama 250 Hackberry Lane Tuscaloosa AL 35487 USA snowden@ua.edu.ORCID https://orcid.org/0009-0007-6215-4549
Robert C ReynoldsDepartment of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham Birmingham AL 35294 USA.
Christina OchsenbauerDepartment of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham Birmingham AL 35294 USA.
Timothy S SnowdenDepartment of Chemistry and Biochemistry, The University of Alabama 250 Hackberry Lane Tuscaloosa AL 35487 USA snowden@ua.edu.ORCID https://orcid.org/0000-0002-6838-1220

Funding

A New Paradigm for HIV Treatment: Targeted Degradation of HIV Reverse Transcriptase via the Ubiquitin-Proteasome PathwayR21AI157362 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI REYNOLDS, ROBERT C · 2021 to 2022
$434k
Investigation of ATV-Based Heterobifunctional Degraders to Combat Growing HIV-1 PR Inhibitor ResistanceR21AI170213 · NIAID · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI OCHSENBAUER, CHRISTINA, SNOWDEN, TIMOTHY S · 2022 to 2023
$423k
NIAID NIH HHS R21 AI157362NIAID NIH HHS R21 AI170213
6 · The paper itself

Abstract

The von Hippel-Lindau (VHL) protein serves as the substrate recognition subunit of the multi-subunit Cullin-2 RING E3 ubiquitin ligase (CRL2

Identifiers

PMID38808246
PMCPMC11130640

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.