ArticleFrontiers in endocrinology2024
Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Effects of oral nutritional supplement on growth and body composition in malnutrition at risk and malnourished children: MARVEL study, a multi-center randomized controlled trial.European journal of nutrition · 2026Trial
- The effect of culinary medicine to enhance protein intake on muscle quality in older adults: a randomized controlled trial.Aging clinical and experimental research · 2025Trial
- The Double-Deficient Older Inpatient: Vitamin D and Vitamin B12 Co-Deficiency Identifies the Greatest Cognitive and Affective Burden.Nutrients · 2026Article
- Preventive Effect ofGut and liver · 2026Observational
- Vitamin B12 improves skeletal muscle mitochondrial biology in aged mice.GeroScience · 2026Article
- Genetically Predicted Homocysteine Levels and B Vitamins on Sarcopenia-Related Traits: Insights From an Observational and Mendelian Randomization Analysis.Food science & nutrition · 2026Article
- Exploring the nexus between inflammation and mobility through the lens of healthy aging: current scenario and future perspectives.Aging clinical and experimental research · 2026Review
- From mechanisms to management: a comprehensive review of sarcopenia in gastric cancer.Frontiers in nutrition · 2026Review
- Association of serological biomarkers with muscle strength and function in sarcopenia: a cross-sectional study.Annals of medicine · 2025Article
- The Role of Methylmalonic Acid in the Risk of Sarcopenia and All-Cause Mortality Among Individuals With Sarcopenia: Evidence From NHANES.Food science & nutrition · 2025Article
- Influence of helicobacter pylori infection on Chinese adult males' body muscle mass: a cross-sectional and cohort analysis.Frontiers in cellular and infection microbiology · 2025Article
- The Relevance of Plant-Based Diets and Micronutrient Supplementation for Body Composition: Data from the VeggieNutri Cross-Sectional Study.Nutrients · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
Introduction: The effects of vitamin B12 metabolism on musculoskeletal health and the exact mechanism have not been fully determined. Our study aimed to assess the association of vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults. Methods: The data from the National Health and Nutrition Examination Survey 2001-2002 were used to investigate the effects of serum vitamin B12 and its biomarkers (homocysteine and methylmalonic acid) on skeletal muscle health. Bone mineral density (BMD), lean mass, gait speed and knee extensor strength were used as indicators for musculoskeletal health. Results: Serum vitamin B12 level was positively correlated with the total and appendicular lean mass (β = 584.83, Conclusions: Vitamin B12 and its biomarkers are closely related to BMD, body composition, muscle strength and physical function in middle-aged and older adults. Vitamin B12 may be an important indicator of musculoskeletal health in the elderly.
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