ArticlePhysics and imaging in radiation oncology2024
Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer.
Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Beyond Couch Correction in Head and Neck Radiotherapy: A Narrative Review of Action-Oriented Positioning Management.Cancers · 2026Review
- Robustness assessment of radiotherapy treatment plans in Switzerland.Zeitschrift fur medizinische Physik · 2026Article
- Dosimetric and robustness evaluation of biaxially rotational dynamic radiation therapy with robust optimization.Journal of applied clinical medical physics · 2025Article
- Dosimetric and radiobiological evaluation of stereotactic radiosurgery using volumetric modulated arc therapy and dynamic conformal arc therapy for multiple brain metastases.Scientific reports · 2025Article
- Dosimetric Comparison of Noncoplanar VMAT Without Rotating the Patient Couch Versus Conventional Coplanar/Noncoplanar VMAT for Head and Neck Cancer: First Report of Dynamic Swing Arc.Advances in radiation oncology · 2025Article
- Dosimetric optimization for dynamic mixed beam arc therapy (DYMBARC).Medical physics · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Background and purpose: Dynamic trajectory radiotherapy (DTRT) has been shown to improve healthy tissue sparing compared to volumetric arc therapy (VMAT). This study aimed to assess and compare the robustness of DTRT and VMAT treatment-plans for head and neck (H&N) cancer to patient-setup (PS) and machine-positioning uncertainties. Materials and methods: The robustness of DTRT and VMAT plans previously created for 46 H&N cases, prescribed 50-70 Gy to 95 % of the planning-target-volume, was assessed. For this purpose, dose distributions were recalculated using Monte Carlo, including uncertainties in PS (translation and rotation) and machine-positioning (gantry-, table-, collimator-rotation and multi-leaf collimator (MLC)). Plan robustness was evaluated by the uncertainties' impact on normal tissue complication probabilities (NTCP) for xerostomia and dysphagia and on dose-volume endpoints. Differences between DTRT and VMAT plan robustness were compared using Wilcoxon matched-pair signed-rank test ( Results: Average NTCP for moderate-to-severe xerostomia and grade ≥ II dysphagia was lower for DTRT than VMAT in the nominal scenario (0.5 %, p = 0.01; 2.1 %, p < 0.01) and for all investigated uncertainties, except MLC positioning, where the difference was not significant. Average differences compared to the nominal scenario were Conclusions: DTRT and VMAT plan robustness to the investigated uncertainties depended on uncertainty direction and location of the structure-of-interest to the target. NTCP remained on average lower for DTRT than VMAT even when considering uncertainties.
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