Evidence map›Paper›PMID 38808066›Full record

ArticleFrontiers in cellular and infection microbiology2024

Using host-mimicking conditions and a murine cutaneous abscess model to identify synergistic antibiotic combinations effective against

Nikita Lyons, Weihui Wu, Yongxin Jin, Iain L Lamont, Daniel Pletzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikita LyonsDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Weihui WuDepartment of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Yongxin JinDepartment of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Iain L LamontDepartment of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Daniel PletzerDepartment of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic drug combination therapy is critical for the successful treatment of infections caused by multidrug resistant pathogens. We investigated the efficacy of β-lactam and β-lactam/β-lactamase inhibitor combinations with other antibiotics, against the hypervirulent, ceftazidime/avibactam resistant

Indexed as

AbscessAnti-Bacterial AgentsDisease Models, AnimalDrug SynergismDrug Therapy, CombinationMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsAnimalsAzabicyclo CompoundsAzithromycinCeftazidimeColistinDrug CombinationsDrug Resistance, Multiple, BacterialFemaleAnti-Bacterial AgentsAzabicyclo CompoundsAzithromycinCeftazidimeColistinDrug Combinationsabscess modelantibiotic synergycheckerboarddrug combinationshigh-densityhost-mimicking conditionsskin infection model

Identifiers

PMID38808066
PMCPMC11130353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.