Evidence map›Paper›PMID 38808064›Full record

ArticleFrontiers in cellular and infection microbiology2024

Kwadwo A Kusi, Linda E Amoah, Festus Kojo Acquah, Nana Aba Ennuson, Abena F Frempong, Ebenezer A Ofori, Kwadwo Akyea-Mensah, Eric Kyei-Baafour, Frank Osei, Augustina Frimpong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kwadwo A KusiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Linda E AmoahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Festus Kojo AcquahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Nana Aba EnnusonDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Abena F FrempongDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Ebenezer A OforiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Kwadwo Akyea-MensahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Eric Kyei-BaafourDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Frank OseiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Augustina FrimpongDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Susheel K SinghCenter for Medical Parasitology at the Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Michael TheisenCenter for Medical Parasitology at the Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Edmond J RemarqueDepartment of Parasitology, Biomedical Primate Research Center, Rijswijk, Netherlands.
Bart W FaberDepartment of Parasitology, Biomedical Primate Research Center, Rijswijk, Netherlands.
Maria BelmonteHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
Harini GaneshanHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
Jun HuangHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States.
Eileen VillasanteMalaria Department, Naval Medical Research Command, Silver Spring, MD, United States.
Martha SedegahMalaria Department, Naval Medical Research Command, Silver Spring, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Diversity in malarial antigens is an immune evasion mechanism that gives malaria parasites an edge over the host. Immune responses against one variant of a polymorphic antigen are usually not fully effective against other variants due to altered epitopes. This study aimed to evaluate diversity in the Plasmodium falciparum antigens apical membrane antigen 1 (PfAMA1) and circumsporozoite protein (PfCSP) from circulating parasites in a malaria-endemic community in southern Ghana and to determine the effects of polymorphisms on antibody response specificity. Methods: The study involved 300 subjects, whose Results: Of the 300 subjects, 171 (57%) had Discussion: These data confirm the presence of a considerable amount of unique, previously unreported amino acid changes, especially within PfCSP. Drivers for this diversity in the Pfcsp gene do not immediately seem apparent, as immune pressure will be expected to drive a similar level of diversity in the

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanMalaria, FalciparumMembrane ProteinsPlasmodium falciparumProtozoan ProteinsAdolescentAdultAntigenic VariationChildChild, PreschoolDNA, ProtozoanEnzyme-Linked Immunosorbent AssayFemaleGenetic VariationGhanaAntibodies, ProtozoanAntigens, Protozoanapical membrane antigen I, Plasmodiumcircumsporozoite protein, ProtozoanDNA, ProtozoanMembrane Proteinsmerozoite surface protein 2, PlasmodiumProtozoan ProteinsGhanamalariaPfAMA1PFCSPplasmodiumpolymorphism

Identifiers

PMID38808064
PMCPMC11132687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.